LP3 Network Free Webinar - Veterinary Compounding, A Customized Approach

Download in electronic PDF format for $25



Search the Complete Journal Archives

Stability of an Oral Liquid Dosage Form of Trovafloxacin Mesylate and Its Quantitation in Tablets Using High-Performance Liquid Chromatography

Author(s):  Gupta Vishnu D

Issue:  May/Jun 2000 - Compounding for the Ear, Nose and Throat
View All Articles in Issue

Abstract:  A high-performance liquid chromatographic assay method for the quantitation of trovafloxacin in film-coated tablets and an oral liquid dosage form (10 mg/mL) prepared from tablets has been developed. The assay method is very simple, precise and accurate, with a percent relative standard deviation of 1.8 based on five injections. The recovery from the tablets and the oral liquid dosage form was very close to the label claims. The method is stability indicating, since the peak from a degraded sample (using sodium hydroxide) did not interfere with the assay procedure. Furthermore, a number of excipients present in the tablets and the oral liquid dosage form did not interfere with the developed method. The oral liquid dosage form gave uniform results and the drug was stable for at least 14 days when stored in an amber-colored glass bottle at 25°C (± 1). The pH of the formulation did not change.

Related Keywords: acetonitrile, antibiotic, assay, degraded, fluoronaphthyridone, high-performance, liquid chromatography, liquid dosage form, method, oral liquid, stability, stable, tablets, trovafloxacin

Related Categories: PEER-REVIEWED, STABILITIES, COMPATIBILITIES

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Stability of an Oral Liquid Dosage Form of Trovafloxacin Mesylate and Its Quantitation in Tablets Using High-Performance Liquid Chromatography Gupta Vishnu D May/Jun 2000 233-235 Buy
Quality-Control Analytical Methods: High-Performance Liquid Chromatography Kupiec Thomas C May/Jun 2004 223 Buy
Stability of Oral Liquid Dosage Forms of Ethacrynic Acid Gupta Vishnu D, Ling Jie May/Jun 2001 232-233 Buy
Quantitation of Testosterone-Cypionate-in-Oil Injection using High Performance Liquid Chromatography Gupta Vishnu D, Pramar Y Jul/Aug 1999 314-315 Buy
Quantitation of Testosterone Propionate in an Injection Using High Performance Liquid Chromatography Gupta Vishnu D Mar/Apr 1999 158-159 Buy
Quantitation of Testosterone in Suspension using High Performance Liquid Chromatography Gupta Vishnu D May/Jun 1999 239-240 Buy
Stability of an Oral Liquid Dosage Form of Glycopyrrolate Prepared from Tablets Gupta Vishnu D Nov/Dec 2001 480-481 Buy
Simple High-Performance Liquid Chromatographic Method for Simultaneous Determination of Fusidic Acid and Betamethasone Dipropionate in a Cream Formulation Peh Kok-Khiang, Tan Yvonne Tze-Fung May/Jun 2000 229-231 Buy
Stability of Oral Liquid Dosage Forms of Glycopyrrolate Prepared with the Use of Powder Gupta Vishnu D Sep/Oct 2003 386-388 Buy
Chemical Stability of Isoniazid in an Oral Liquid Dosage Form Gupta Vishnu D, Sood Arun Mar/Apr 2005 165-166 Buy