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Stability of Morphine-Ketamine Mixtures in 0.9% Sodium Chloride Injection Packaged in Syringes, Plastic Bags and MEDICATION CASSETTEª Reservoirs

Author(s):  Roy Julie J, Hildgen Patrice

Issue:  May/Jun 2000 - Compounding for the Ear, Nose and Throat
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Abstract:  The purpose of this study was to determine the stability of different intravenous mixtures of morphine and ketamine in 0.9% sodium chloride injection, USP packaged in plastic syringes, plastic bags and MEDICATION CASSETTE™ reservoirs (SIMS-Deltec, Inc., Minneapolis, MN). Nine morphine (1-, 10- and 25-mg/mL) and ketamine (1-, 10- and 25-mg/mL) mixtures in syringes; two morphine and ketamine mixtures (1 mg/mL and 25 mg/mL of each drug) in plastic bags; and one morphine and ketamine mixture (25 mg/mL of each drug) in a MEDICATION CASSETTE reservoir were investigated using a high-performance liquid chromatography analytical technique to measure drug concentrations after one to six days at room temperature. No loss of drug was observed during the study.

Related Keywords: Accusolv, acetonitrile, chromatograph, injection, intravenous, ketamine, medication cassette, morphine, plastic bags, plastic syringe, reagents, reservoirs, stability, temperature

Related Categories: PEER-REVIEWED, STABILITIES, COMPATIBILITIES

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