Medisca's Hair Care Compounding Solutions

Download in electronic PDF format for $25

Search the Complete Journal Archives

Dry Heat Sterilization of Parenteral Oil Vehicles

Author(s):  Kupiec Thomas C, Matthews Parrish, Ahmad Riaz

Issue:  May/Jun 2000 - Compounding for the Ear, Nose and Throat
View All Articles in Issue

Abstract:  The purpose of this study was to evaluate the effect of temperature and time on the dry-heat sterilization conditions of cottonseed, peanut and sesame-seed oils used as vehicles for parenteral drugs. The three oils were individually spiked with Bacillus subtilis spores and exposed to dry heat at four different temperatures (150, 160, 170, and 180°C) for three different time intervals (one, 1.5 and two hours). Following inoculation and dry-heat sterilization, samples were placed in a laminar airflow hood and processed according to <71>, “Sterility Tests” of the USP XXIV/NF 19 using thioglycolate broth and fluid D.1 The specimens were then placed into an incubator at 30° C and observed for three, five and seven days for bacterial growth. All tests were performed in triplicate. Positive and negative controls were conducted with each group. All three oils were found to be free of viable Bacillus subtilis following dry-heat sterilization at 150, 160, 170 and 180°C for one, 1.5 and two hours after incubation for seven days. The positive controls were positive for observed growth and the negative controls had no observed bacterial growth. Dry-heat sterilization of the three oils at 150°C for one hour appeared to be sufficient for time and temperature conditions. However, the authors recommend dry-heat sterilization procedures be validated for each product.

Related Keywords: bacillus subtilis, cottonseed oil, dry-heat, edible oils, endospores, fluid d, heat treatment, high-temperature, microbial, oil, oil vehicles, parenteral oil, peanut oil, sesame-seed oil, stability, sterilization, thioglycolate medium


Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Dry Heat Sterilization of Parenteral Oil Vehicles Kupiec Thomas C, Matthews Parrish, Ahmad Riaz May/Jun 2000 223 Buy
Oleaginous Vehicles, Featured Excipient: Allen Loyd V Jr Nov/Dec 2000 470 Buy
Effect of Emulsifier Pairs on Physical Stability of Emulsions Containing Three Different Natural Oils Boonme Prapaporn, Maneenuan Duangkhae Nov/Dec 2014 516-519 Buy
Preventing Leakage in Oil-Filled Capsules Allen Loyd V Jr Sep/Oct 1999 364 Buy
Premixed Oil Phase for Preparing Oil-in-Water (O/W) Emulsions Allen Loyd V Jr Nov/Dec 2003 463 Buy
Experimenting with a New Emulsifying Agent (Tahini) in Mineral Oil Emulsion Al-Achi Antoine, Greenwood Robert, Akin-Isijola Austin Jul/Aug 2000 315-317 Buy
Physical Stability of Coconut Oil Lotions Formulated Using a Hydrophile-lipophile System of Various Emulsifier Pairs Boonme Prapaporn, Maneenuan Duangkhae, Channarong Sunee Jul/Aug 2013 347-350 Buy
Estradiol Valerate 40-mg/mL in Oil Injection Allen Loyd V Jr Nov/Dec 2015 509 Buy
Rice Bran Oil: Preparation and Evaluation of Novel Liquisolid and Semisolid Formulations Ammar Hussein O, Al-Okbi Sahar Y, Mostafa Dina M, Helal Amr M Nov/Dec 2012 516-523 Buy
Tea Tree Oil Acne Gel Allen Loyd V Jr Mar/Apr 2011 165 Buy