LP3 Network Free Webinar - Veterinary Compounding, A Customized Approach

Download in electronic PDF format for $25



Search the Complete Journal Archives

The Basics of Compounding: Compounding Powder-Filled Capsules

Author(s):  Allen Loyd V Jr

Issue:  May/Jun 1999 - Compounding for Animals
View All Articles in Issue

Abstract:  The capsule is probably the most versatile of all dosage forms. In this article, the author discusses composition, preparation methods/techniques (source of equipment and materials, preparation of the powder, selection of the right capsule size, capsule-filling devices, sealing capsules, cleaning and packaging), physicochemical uniqueness (incompatibilities, capsules within capsules, tablets within capsules), quality control, storage/labeling and stability. Tables provide information regarding weight, in milligrams, of different powders that can be contained in various sized capsules; bulk densities of typical pharmaceutical actives and excipients; approximate capacities of capsules in milliliters; and excipients that can be used to enhance compatibility of eutectic mixtures. An example formula is provided for Capsule With Dry Powder Fill. In summary, capsules are relatively easy to manufacture, and they are amenable to small-scale compounding by the pharmacist to prepare specific products for individual patients’ needs.

Related Keywords: gelatin, Rule of Sixes, fill volume, bulk density, Rule of Sevens, encapsulation, hand filling, machine filling, incompatibilities

Related Categories: SUPPORT

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
The Basics of Compounding: Compounding Powder-Filled Capsules Allen Loyd V Jr May/Jun 1999 209 Buy
Rule of Sixes for Filling Hard-Shell Gelatin Capsules, Rule Nash Robert A Jan/Feb 1997 40-41 Buy
Technology Spotlight: Liquid-Filling Machines Braverman Bob, Northcutt Kyle Nov/Dec 2002 439-440 Buy
Technology Spotlight: Capsule-Filling Machines Allen Loyd V Jr Jan/Feb 2002 31 Buy
Preventing Leakage in Oil-Filled Capsules Allen Loyd V Jr Sep/Oct 1999 364 Buy
Progesterone 100-mg Semisolid-Fill, Hard-Gelatin Capsules Allen Loyd V Jr Sep/Oct 1999 396 Buy
Triple Estrogen 2.5-mg Semisolid-Filled Hard-Gelatin Capsules Allen Loyd V Jr May/Jun 1997 187 Buy
Standard Operating Procedure for Quality Assessment of Powder-Filled, Hard-Gelatin Capsules Allen Loyd V Jr May/Jun 1999 232-233 Buy
Basics of Compounding: Special Capsules Allen Loyd V Jr May/Jun 2016 209-214 Buy
The Rule of Seven Al-Achi Antoine, Greenwood Robert May/Jun 1997 191 Buy