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Preservation, Sterilization, and Sterility Testing of Ophthalmic Preparations

Author(s):  Allen Loyd V Jr

Issue:  May/Jun 1998 - Compounding Ophthalmics
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Abstract:  A number of factors are involved in the selection of a preservative for ophthalmics. This discussion covers physicochemical characteristics, uniqueness and incompatibilities of common preservatives (benzalkonium chloride, benzethonium chloride, chlorobutanol, the parabens, mercurial compounds and testing of preservative effectiveness. A table provides information regarding common preservatives used in ophthalmic, otic and nasal products. A sidebar provides a primer on sterilization and sterility testing.

Related Keywords: Benzalkonium chloride, Benzethonium chloride, Chlorobutanol, Filtration, Mercurial, Methylparaben, Parabens, Phenymurcuric, Propylparaben, Thimerosal

Related Categories: OPHTHALMICS, STERILE PREPARATIONS, QUALITY CONTROL, UNITED STATES PHARMACOPEIA CONVENTIONS

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