LP3 Network Free Webinar - Veterinary Compounding, A Customized Approach

Download in electronic PDF format for $25



Search the Complete Journal Archives

L-Arginine and Ascorbic Acid for Diabetic Foot Ulcers

Author(s):  Gorman Shellie

Issue:  Mar/Apr 2000 - Compounding for Diabetes Patients
View All Articles in Issue

Abstract:  Diabetic foot ulcers are the most common cause of nontraumatic amputations and are responsible for 25% of all hospitalizations of patients with diabetes. Poor blood flow due to vascular endothelial dysfunction is considered the underlying cause of this condition. L-arginine is converted in the body to nitric oxide, a potent vasodilator, so supplementation with it may help increase vascular blood flow to ulcerated areas. Ascorbic acid has also been shown to improve endothelial-dependent vasodilation in diabetic patients. Together these nutrients may aid healing of diabetic foot ulcers. The author discusses physiology and topical treatment of diabetic foot ulcers. She then briefly describes ingredients in two sample formulations included with the article that may be of assistance, L-Arginine and Ascorbic Acid Hydrating Ulcer Gel, and L-Arginine and Ascorbic Acid in PLO (L-arginine, ascorbic acid, zinc sulfate, methylcellulose, propylene glycol, methylparaben, purified water, poloxamers, lecithin and isopropyl palmitate). She concludes that use of an appropriate topical dressing to treat diabetic foot ulcers can accelerate healing. While further studies are needed to determine the benefit from L-arginine and ascorbic acid, sufficient data exist to imply benefits for the diabetic patient.

Related Keywords: diabetic foot ulcers, amputations, L-arginine, dry wound, wet wound, PLO gel, ascorbic acid, zinc sulfate, astringent antiseptic, antioxidant, vasodilator, methylcellulose, propylene glycol, methylparaben, purified water, poloxamers, lecithin, isopropyl palmitate

Related Categories: DIABETES, WOUND CARE

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
L-Arginine and Ascorbic Acid for Diabetic Foot Ulcers Gorman Shellie Mar/Apr 2000 94 Buy
Case Report: Wound Care of a Diabetic Foot Ulcer Wynn Tom Jul/Aug 2004 265 Buy
Wetting and/or Solubilizing Agents, Featured Excipient: Allen Loyd V Jr Jul/Aug 2001 310 Buy
Options in Wound Care Kincaid Michele R Mar/Apr 2002 92 Buy
Current Topical Treatments in Wound Healing - Part 1 Helmke Christopher D Jul/Aug 2004 269 Buy
A Need for Propylene Glycol-Free Ascorbic Acid Oral Liquid McElhiney Linda F Nov/Dec 2004 458-460 Buy
Quality Control Analytical Methods: Aqua Pura: Water Purification Systems and United States Pharmacopeia Waters for the Compounding Pharmacy, Part 2: USP Waters: Experts at the United States Pharmacopeia Answer Compounders' Questions Schnatz Rick, Hernandex-Cardoso Antonio May/Jun 2011 224-232 Buy
Profile of a Practice: Ward Drug Company Diabetic Shoppe and Prescription Compounding Center Vail Jane Jan/Feb 2003 21 Buy
The Clinical Pharmacist's Role in Compounding for the Diabetic Patient Harshbarger Robert, Harshbarger Diana Mar/Apr 2000 84 Buy
Compounding with Sucralfate for the Treatment of External Wounds Wynn Tom, Williams LaVonn A Jan/Feb 2009 25-29 Buy