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Stability of Extemporaneously Prepared Sterile Testosterone Solution in 0.9% Sodium Chloride Solution Large-Volume Parenterals in Plastic Bags

Author(s):  White C Michael, Quercia Robert

Issue:  Mar/Apr 1999 - Compounding for Men's Health
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Abstract:  The stability of extemporaneously compounded testosterone sterile solution in large-volume parenterals (LVPs) in plastic bags containing 0.9% sodium chloride solution was evaluated. Two LVPs were prepared; one remained at room temperature and the other was refrigerated. Samples were withdrawn and frozen at 0, 1, 3, 6, 9 and 24 hours. The concentrations of the samples at each time point were determined using a specific radioimmunoassay. Stability was defined as 90% or greater of the original concentration remaining.

No color change was observed at any time during the study. Intravenous testosterone solutions compounded extemporaneously in 0.9% sodium chloride solution containing LVPs in plastic bags were stable for nine hours at 5°C but were unstable at 24°C after only one hour.

Related Keywords: LVP

Related Categories: HRT, PEER-REVIEWED, STABILITIES, COMPATIBILITIES

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