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Stability of Indomethacin in 0.9% Sodium Chloride Injection

Author(s):  Gupta Vishnu D, Maswoswe J

Issue:  Mar/Apr 1998 - Pain Management
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Abstract:  The stability of indomethacin (from indomethacin sodium trihydrate powder for injection) in preservative-free 0.9% sodium chloride injection has been studied using a stabilityindicating high-performance liquid chromatography assay method. The method described is precise and accurate, with a percent relative standard deviation of 0.7% based on five readings. The 0.1-mg/mL solutions were stable for at least ten days when stored at room temperature in 10-mL plastic vials in which the sodium chloride injections are marketed. The solutions remained clear throughout the study; and pH values did increase by about 0.5 units, since the admixtures were not buffered.

Related Categories: PEER-REVIEWED, STABILITIES, COMPATIBILITIES

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