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Stability of Milrinone Lactate 200 mcg/mL in 5% Dextrose Injection and 0.9% Sodium Chloride Injection

Author(s):  Wong Frances, Gill Mark A

Issue:  Mar/Apr 1998 - Pain Management
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Abstract:  The stability of milrinone lactate 200 µg/mL in either 5% dextrose injection or 0.9% sodium chloride injection was studied. The solutions were prepared in polyvinyl chloride bags and aliquots of 10 mL were withdrawn at times zero, one, three, seven and 14 days at room (20 to 25°C) and refrigerated (2 to 8°C) temperatures. The samples were then stored at -20°C and analyzed for potency using a stability-indicating high-performance liquid chromatography assay procedure. Stability was defined as 90% or greater of the original concentration remaining. Samples were inspected visually and no color change, haziness or precipitation was observed at any time during the study.

Milrinone lactate 200 µg/mL mixed in either 5% dextrose injection or 0.9% sodium chloride injection is stable at room or refrigerated temperatures for 14 days.

Related Categories: PEER-REVIEWED, STABILITIES, COMPATIBILITIES

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