Download in electronic PDF format for $25

Kalchem International - Chemicals and Compounding Supplies

Search the Complete Journal Archives

Clinical Application of Ketamine Ointment in the Treatment of Sympathetically Maintained Pain

Author(s):  Crowley Kenton L, Flores John A, Hughes Christine N, Iacono Robert P

Issue:  Mar/Apr 1998 - Pain Management
View All Articles in Issue

Abstract:  The objective of this study was to determine the clinical efficacy of topical ketamine in relieving sympathetically maintained pain, including complex regional pain syndrome types I and II, involving the upper and/or lower extremities. In an open clinical pilot study of five referral patients diagnosed with sympathetically maintained pain who were unresponsive to conventional modalities, a single dose of topical ketamine was administered. Age, gender, duration or degree of disease and concurrent medication were not controlled. Ketamine was prepared for transdermal delivery in pluronic lethicin organogel (PLO) in calibrated applicators. Concentrations ranged from 10 to 150 mg/mL. Dosage ranged from 10 mg to 700 mg per single application. Each dosage was determined clinically based on location and surface area of involvement. Pain intensity was measured using a validated numeric analogue scale (NAS). Ketamine in PLO applied to the upper and/or lower extremities with sympathetically maintained pain resulted in significant pain reduction relative to pretreatment NAS of 65% to 100%. Initial response was within 20 seconds to three minutes, with NAS rating 15 minutes postapplication. No reported side effect occurred on patient follow-up at 24 and 48 hours. Single-dose, topical application of ketamine in PLO (patent pending) appears clinically effective in relieving sympathetically maintained pain of the extremities without apparent side effects. Further controlled studies are warranted to define patient selection, optimize dosage and validate the prominent analgesic effects obtained in this heretofore difficult- to-treat pain syndrome. This was an independent study in joint cooperation with representatives from the University of California at Irvine, Loma Linda University Medical Center and private practice.

Related Keywords: Lecithin, Organogel, Pluronic

Related Categories: DERMATOLOGY, PAIN MANAGEMENT

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
The History of Pluronic Lecithin Organogel: An Interview With Marty Jones, BSPharm, FACA, FIACP Allen Loyd V Jr May/Jun 2003 180-183 Buy
Pluronic Lecithin Organogel for Local Delivery of Anti-Inflammatory Drugs Frankum James, Ramsay Dale, Das Nandita G, Das Sudip K Mar/Apr 2004 101 Buy
Morphine Sulfate 50 mg/mL in Pluronic Lecithin Organogel Allen Loyd V Jr May/Jun 2009 244 Buy
Oxycodone Hydrochloride 10 mg/mL in Pluronic Lecithin Organogel Allen Loyd V Jr May/Jun 2009 245 Buy
Bioavailability of Promethazine in a Topical Pluronic Lecithin Organogel: A Pilot Study Glisson James K, Wood Rebecca L, Kyle Patrick B, Cleary John D May/Jun 2005 242-246 Buy
The Use of Pluronic Lecithin Organogels in the Transdermal Delivery of Drugs Bramwell Bethany L, Williams LaVonn A Jan/Feb 2012 62-63 Buy
In Vitro Percutaneous Absorption of Ketoprofen and Testosterone: Comparison of Pluronic Lecithin Organogel vs. Pentravan Cream Lehman Paul A, Raney Sam G May/Jun 2012 248-252 Buy
Preparation and In Vitro Evaluation of a Pluronic Lecithin Organogel Containing Ricinoleic Acid for Transdermal Delivery Boddu Sai HS, Bonam Sindhu Prabha, Wei Yangjie, Alexander Kenneth May/Jun 2014 256-261 Buy
Effect of Formulation pH on Transdermal Penetration of Antiemetics Formulated in Poloxamer Lecithin Organogel Woodall Rachel, Arnold John J, McKay Doug, Abill C Scott May/Jun 2013 247-253 Buy
Evaluation of the Stability of Fluoxetine in Pluronic Lecithin Organogel and the Determination of an Appropriate Beyond-use Date Peacock Gina F, Sauvageot Jurgita May/Jun 2014 253-255 Buy