Introducing Medisca Nutraceuticals

Download in electronic PDF format for $25



Search the Complete Journal Archives

Bacterial Endotoxins and Pyrogens

Author(s):  Jones Marty

Issue:  Jul/Aug 2001 - Sterile Product Compounding
View All Articles in Issue

Abstract:  The etiologic role of sterile injections in the development of pyrogenic reactions should be of concern to all pharmacists involved in aseptic compounding. In this article, the author discusses bacterial endotoxins, testing for pyrogens, pyrogenic reactions from the use of gentamicin for injection and intrathecal limits for pyrogens. He concludes that the use of pyrogen-free water is the single most important factor in reducing the risk of pyrogenic reactions. End-product testing for bacterial content, potency and endotoxin load ensures the effectiveness and safety of the compounded medication. Clinical concern can be reduced by adhering to quality-control guidelines for policy and procedures in daily practice.

Related Keywords: Endotoxins, bacterial, Pyrogens, Horseshoe crab, Limulus amebocyte lysate LAL

Related Categories: STERILE PREPARATIONS, SUPPORT, UNITED STATES PHARMACOPEIA CONVENTIONS

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Bacterial Endotoxins and Pyrogens Jones Marty Jul/Aug 2001 259 Buy
Quality-Control Analytical Methods: Endotoxins: Essential Testing for Pyrogens in the Compounding Laboratory, Part 3: A Simplified Endotoxin Test Method for Compounded Sterile Preparations Cooper James F Jan/Feb 2011 49-54 Buy
Quality Control Analytical Methods: Pharmacopeial Bacterial Endotoxins Test Chapters Dawson Michael E Jul/Aug 2010 317-320 Buy
Quality Control Analytical Methods: Endotoxins: Essential Testing for Pyrogens in the Compounding Laboratory, Part 1 Dubczak John, Latta Kenneth S, Hedman Hilary, Smith Donald R Sep/Oct 2010 407-414 Buy
Basics of Compounding: Application of the United States Pharmacopeia Bacterial Endotoxins Test to Compounded Sterile Preparations Dawson Michael F Jan/Feb 2006 36-39 Buy
Quality-Control Analytical Methods: Endotoxins: Essential Testing for Pyrogens in the Compounding Laboratory, Part 2 Cooper James F, Chakrabarty Kaushik, McGuire Jason, Zolner William J, Jones Vann, Hedman Hilary Nov/Dec 2010 493-506 Buy
Quality Assurance and Quality Control, Part 2 Akers Michael J May/Jun 2015 215-221 Buy
Testing for Bacterial Endotoxins Jelinek Todd Sep/Oct 1998 379 Buy
Establishing Benchmark Rates of Microbial and Bacterial Endotoxin Contamination for Radiopharmaceuticals Compounded in Commerical Nuclear Pharmacy Settings Weatherman Kara D, Augustine Samuel, Christoff Jeffrey, Galbraith Wendy Mar/Apr 2013 168-174 Buy
Stability Issues for Compounding Extemporaneously Prepared Oral Formulations for Pediatric Patients Schotik Debora Jan/Feb 2001 9 Buy