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Considerations for Percutaneous Absorption

Author(s):  Newton Stephen J, Cook Jennifer M

Issue:  Jul/Aug 2010 - Sterile Compounding
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Abstract:  Percutaneous absorption is affected by numerous factors. Whether they are internal or external factors, the compounding pharmacist must collectively consider these variables in order to provide a safe and effective topical preparation for the patient. By considering the physiochemical and dermal factors that affect percutaneous absorption of a medication, an effective topical medication can be formulated to treat the patient’s specific indication. Furthermore, this article will review the background information necessary to formulate transdermal prescriptions for their patients.

Related Keywords: Stephen J. Newton, RPh, Jennifer M. Cook, PharmD, percutaneous absorption, topical preparations, transdermal administration, skin hydration, skin damage, dermal lipids, pluronic solubility, formulation, solid lipid nanoparticles, particle size, partition coefficient


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