Introducing Medisca Nutraceuticals

Download in electronic PDF format for $25



Search the Complete Journal Archives

Compounding Rifampin Suspensions with Improved Injectability for Nasogastric Enteral Feeding Tube Administration

Author(s):  de Villiers Melgardt M, Vogel Laura, Bogenschutz Monica C, Fingerhut Bonnie J, D'Silva Joseph B, Moore Anne

Issue:  May/Jun 2010 - Pain Management
View All Articles in Issue

Abstract:  Often medications that have to be administered to patients via a nasogastric enteral feeding tubes are only available as tablets and capsules with no suitable commercial liquids alternatives. In such situations, pharmacists and nurses have to compound the tablets and capsule contents into liquid suspension formulations for dosing. The risk of occlusion of the enteral tubes during administration is reduced by employing liquid suspensions that are composed of small and uniform particles, not subject to rapid rates of settling, resistant to caking, and easily and uniformly resuspended upon agitation. Present techniques often employ a manual process, such as a mortar and pestle, to accomplish the particle size reduction and subsequent incorporation into a suitable liquid diluent. A new compounding device has been invented that employs an automated wet-milling process in a single-use disposable plastic container to compound the suspensions. The two processes were compared using Rifampin capsules and various liquid

Related Keywords: Melgardt M. de Villiers, PhD, Laura Vogel, PharmD, Monica C. Bogenschutz, PharmD, Bonnie J. Fingerhut, BS, Joseph B. D'Silva, PhD, Anne Moore, Ingenieur ENSCP, DEA, nasogastric enteral feeding tube, liquid suspension preparations, rifampin, antibiotic, antimicrobial agent, antitubercular agent, tuberculosis, nasogastric tube injectability test, particle size, tube blockage

Related Categories: FORMULATIONS, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, QUALITY CONTROL, DOSAGE FORMS/DRUG CARRIERS, INFECTIOUS DISEASE

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Compounding Rifampin Suspensions with Improved Injectability for Nasogastric Enteral Feeding Tube Administration de Villiers Melgardt M, Vogel Laura, Bogenschutz Monica C, Fingerhut Bonnie J, D'Silva Joseph B, Moore Anne May/Jun 2010 250-256 Buy
Recommendations for Compounding Medications for Feeding Tube Administration Klang Mark Jul/Aug 2010 276-282 Buy
Nasogastric Tube/Percutaneous Endoscopic Gastrostomy Tube Suspension Formula Allen Loyd V Jr Jul/Aug 2000 304 Buy
Compounding for Diabetic Patients:An Interview with Paul Lofholm, PharmD Allen Loyd V Jr Nov/Dec 1997 381-385 Buy
Rapid-Dissolve Technology: An Interview With Loyd V. Allen, Jr., PhD, RPh Allen Loyd V Jr Nov/Dec 2003 449-450 Buy
Safe Cytotoxic Drug Preparation Using a Closed-system Transfer Device: Technical and Practical Evaluation of a New Device (Vialshield/Texium) Comparatively to a Reference One (Phaseal) Garrigue Philippe, Montana Marc, Ventre Christophe, Savry Amadine, Gauthier-Villano Laurence, Pisano Pascale, Pourroy Bertrand Mar/Apr 2016 148-154 Buy
Long-term Stability of Cocaine Hydrochloride Aqueous Solution 50 mg/mL (5%) at Room Temperature and at 5°C ± 3°C in Glass Bottles Dewulf Joseph, Hecq Jean-Daniel, Huvelle Sophie, Godet Marie, Gillet Patricia, Jamart Jacques, Galanti Laurence M May/Jun 2015 268-270 Buy
Technology Spotlight: Tube Sealers Jones Michael, Adams Susan May/Jun 2003 206 Buy
Fluconazole 1-mg/mL Liquid for Nasogastric Tube Administration Allen Loyd V Jr Sep/Oct 2006 383 Buy
Initial Selection of Antiemetics in End-of-Life Care: A Retrospective Analysis Tolen Laura, McMath Jill A, Alt Calvin, Weschules Douglas J, Knowlton Calvin H, McPherson Mary Lynn Mar/Apr 2006 147-153 Buy