Introducing Medisca Nutraceuticals

Download in electronic PDF format for $25



Search the Complete Journal Archives

Evaluation of a Simple Method for Visual Detection of Microprecipitates in Blends of Parenteral Drug Solutions Using a Focussed (Tyndall) Light Beam

Author(s):  Veggeland Turid, Brandl Martin

Issue:  Jan/Feb 2010 - Pediatrics and Wellness
View All Articles in Issue

Abstract:  The formation of microprecipitates (subvisible particles) is a critical factor when blending parenteral drug solutions prior to or during intravenous administration to a patient. In cases where compatibility is not documented, analytical screening of such mixtures for physical incompatibility would give a safer foundation for secure administration of such blends to patients. The aim of this article is to report our experiences with visual screening using a focussed (Tyndall) light beam for the detection of microprecipitates within blends of drug solutions, a method which may be used in any hospital pharmacy without use of advanced analytical instrumentation. A selection of clinically applied drug solutions was tested for precipitation upon blending in a proportion of 1:1. In order to reduce potential background particle burden, the solutions were filtered through 0.2 micrometer pore size filters prior to mixing. To detect potential precipitation, the solutions were visually inspected using two different types

Related Keywords: Turid Veggeland, Martin Brandl, parenteral preparations, microprecipitates, precipitates, physical incompatibility, focussed light beam, Tyndall light, compatibility, visual inspection, standard operating procedure

Related Categories: PARENTERALS, PEER-REVIEWED, SOPs, STABILITIES, COMPATIBILITIES

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Evaluation of a Simple Method for Visual Detection of Microprecipitates in Blends of Parenteral Drug Solutions Using a Focussed (Tyndall) Light Beam Veggeland Turid, Brandl Martin Jan/Feb 2010 78-81 Buy
Standard Operating Procedure: Incubator Temperature Monitoring Allen Loyd V Jr May/Jun 2003 228-229 Buy
Standard Operating Procedure: Procedures in the Event of Nonconformance of Bulk Chemicals or Compounded Preparations Allen Loyd V Jr Sep/Oct 2006 381 Buy
Quality Control: Standard Operating Procedures--An Essential Tool for Developing Quality Preparations Ashworth Lisa D May/Jun 2007 226-229 Buy
Developing Standard Operating Procedures Allen Loyd V Jr May/Jun 2002 224-225 Buy
Physical Compatibility of Calcium Acetate and Potassium Phosphates in Parenteral Nutrition Solutions Containing Aminosyn II Zhang Yanping, Xu Quanyun, Trissel Lawrence A, Baker Mary B Sep/Oct 1999 415-420 Buy
Standard Operating Procedure: Washing Glassware and Equipment Used in Compounding Nonsterile Preparations Allen Loyd V Jr Nov/Dec 2005 470 Buy
Physical Assessments of Lipid Injectable Emulsions via Microscopy: A Comparison to Methods Proposed in the United States Pharmacopeia Chapter <729> Driscoll David F, Nehne Jorg, Horst Peterss, Klutsch Karsten, Bistrian Bruce R, Wilhelm Niemann Jul/Aug 2006 309-315 Buy
Obtaining Accreditation by the Pharmacy Compounding Accreditation Board, Part 2: Developing Essential Standard Operating Procedures Cabaleiro Joe Sep/Oct 2007 397-398 Buy
Standard Operating Procedure: Sterility Test for Ophthalmic Solutions Allen Loyd V Jr May/Jun 2006 218 Buy