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Diverse Challenges in Pediatric Compounding: Treating Pulmonary Hypertension, Uncombable Hair Syndrome, and Acanthamoeba keratitis

Author(s):  Muller George, Young Thomas W, Reina Rachel, Caldwell Delmar R

Issue:  Jan/Feb 2010 - Pediatrics and Wellness
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Abstract:  The market for commercially manufactured drugs for pediatric patients is smaller than that for adults, and most of the medications currently used to treat children, including many over-the-counter products, have not been clinically studied in the pediatric population. Thus a customized medication that is formulated to meet the unique needs of the pediatric patient and that can be quickly adjusted to more effectively address a child’s changing medical needs can be essential to a successful therapeutic outcome. Compounding pharmacists are often faced with the demand for a novel pediatric preparation that overcomes the patient’s taste aversions or resistance to a particular dosage form, and successful treatment can depend on the compounder’s problem-solving skills and therapeutic innovation. In this article, we describe the effective treatment of three children whose medical needs were unmet by manufactured medications. The formulations for the preparations used are also provided.

Related Keywords: George Muller, RPh, Thomas W Young, MD, Rachel Reina, MD, Delmar R Caldwell, MD, children, dosage forms, sildenafil suspension, pulmonary hypertension, case reports, formulations, biotin suspension, uncombable hair syndrome, Acanthamoeba keratitis, Baquacil ophthalmic solution, eye disorders, hair growth disorders, cardiovascular disorders, vision loss, eye pain

Related Categories: DERMATOLOGY, FORMULATIONS, PEDIATRICS, CASE REPORTS, CARDIOLOGY, DOSAGE FORMS/DRUG CARRIERS

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