Medisca's Hair Care Compounding Solutions

Download in electronic PDF format for $25

Search the Complete Journal Archives

The Release and Transdermal Penetration of Baclofen Formulated in a Poloxamer Lecithin Organogel

Author(s):  Arnold John J, Asbill Scott

Issue:  Nov/Dec 2009 - Geriatric Compounding
View All Articles in Issue

Abstract:  The purpose of this study was to evaluate the in vitro release and ex vivo penetration of baclofen following incorporation into a 2% poloxamer lecithin organogel. Franz cells were utilized for both the release and penetration studies. Semi-permeable dialysis membranes were used for the release testing, and porcine skin was used as the model skin for the penetration study. Baclofen release and penetration at predetermined time points were assessed using high-performance liquid chromatographic analysis. Results demonstrated that baclofen release from the poloxamer lecithin organogel was significantly higher than its penetration through porcine skin. The amount of baclofen released by the poloxamer lecithin organogel was linear up to 12 hours. Approximately 20% of applied drug was released over the duration of the study period. In comparison with drug released, the ex vivo penetration of baclofen through porcine skin was very low with only minute detectable quantities (significantly less than 1%) after the 12-ho

Related Keywords: John J. Arnold, PhD, Scott Asbill, PhD, baclofen, transdermal delivery, topical preparations, skin penetration, poloxamer lecithin organogel, dermal application, formulation, PLO, muscle relaxant


Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
The Release and Transdermal Penetration of Baclofen Formulated in a Poloxamer Lecithin Organogel Arnold John J, Asbill Scott Nov/Dec 2009 569-571 Buy
Effect of Formulation pH on Transdermal Penetration of Antiemetics Formulated in Poloxamer Lecithin Organogel Woodall Rachel, Arnold John J, McKay Doug, Abill C Scott May/Jun 2013 247-253 Buy
Veterinary Transdermal Medications: A to Z Davidson Gigi S Mar/Apr 2003 106 Buy
In Vitro Skin Penetration and Skin Content of Progesterone from Various Topical Formulations Heustess Allie, Asbill Scott, Eagerton David, Arnold John Nov/Dec 2014 512-515 Buy
Skin Permeation and Antinociception of Compounded Topical Cyclobenzaprine Hydrochloride Formulations Bryson Evan, Hartman Rachel, Arnold John, Gorman Greg, Sweitzer Sarah.Asbill Scott Mar/Apr 2015 161-166 Buy
Skin Penetration and Antinociception of Topical Gabapentin Formulations Bryson Evan, Asbill Scott, Sweitzer Sarah Nov/Dec 2014 504-511 Buy
Preparation and In Vitro Evaluation of a Pluronic Lecithin Organogel Containing Ricinoleic Acid for Transdermal Delivery Boddu Sai HS, Bonam Sindhu Prabha, Wei Yangjie, Alexander Kenneth May/Jun 2014 256-261 Buy
Effect of Penetration Enhancers on the Percutaneous Delivery of Pain Management Actives Trimble John, Light Bob May/Jun 2016 250-256 Buy
Analgesic Efficacy and Transdermal Penetration of Topical Gabapentin Creams: Finding an Optimal Dose and Pre-treatment Time Heustess Allie, Spigener Shuler, Sweitzer Sarah, Romero-Sandoval Alfonso, Asbill Scott Mar/Apr 2015 167-173 Buy
The History of Pluronic Lecithin Organogel: An Interview With Marty Jones, BSPharm, FACA, FIACP Allen Loyd V Jr May/Jun 2003 180-183 Buy