LP3 Network Free Webinar - Veterinary Compounding, A Customized Approach

Download in electronic PDF format for $25



Search the Complete Journal Archives

Chemical Stability of Scopolamine Hydrobromide Nasal Solution

Author(s):  Gupta Vishnu D

Issue:  Sep/Oct 2009 - Veterinary Compounding
View All Articles in Issue

Abstract:  The chemical stability of scopolamine hydrobromide in nasal solution has been studied by using a stability-indicating high-performance liquid chromatographic assay method that was developed in our laboratory. The concentrations of the drug were directly related to peak heights, and the percent relative standard deviation based on five injections was 0.4. The products of decomposition and excipients present in the dosage forms did not interfere with the developed assay method. The nasal solution was stable for at least 42 days when stored in amber-colored glass bottles at room temperature. The physical appearance and the pH value of the nasal solution did not change during the study period.

Related Keywords: Vishnu D. Gupta, PhD, scopolamine, hyoscine, anticholinergic drug, nausea, antinausea agent, stability, nasal solution, internasal administration

Related Categories: GASTROENTEROLOGY, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, DOSAGE FORMS/DRUG CARRIERS, NEUROLOGY, STORAGE

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Chemical Stability of Scopolamine Hydrobromide Nasal Solution Gupta Vishnu D Sep/Oct 2009 438-439 Buy
Wetting and/or Solubilizing Agents, Featured Excipient: Allen Loyd V Jr Jul/Aug 2001 310 Buy
Physico-chemical Stability of MabThera Drug-product Solution for Subcutaneous Injection under In-use Conditions with Different Administration Materials Mueller Claudia, Dietel Elde, Heynen Severin R, Nalenz Heiko, Goldbach Pierre, Mahler Hanns-Christian, Schmidt Johannes, Grauschopf Ulla, Schoenhammer Karin May/Jun 2015 261-267 Buy
Compounding Ear, Nose and Throat Preparations Allen Loyd V Jr May/Jun 2000 164 Buy
Chemical Stability of Brompheniramine Maleate in an Oral Liquid Dosage Form Gupta Vishnu D, Gupta Vikas S Jan/Feb 2011 78-80 Buy
Transdermals: The Skin as Part of a Drug Delivery System Allen Loyd V Jr Jul/Aug 2011 308-315 Buy
Chemical Stability of Perphenazine in Oral Liquid Dosage Forms Gupta Vishnu D Nov/Dec 2005 484-486 Buy
Chemical Stability of Hydrocortisone in an Oral Liquid Dosage Form without Suspending Agents Gupta Vishnu D May/Jun 2007 259-261 Buy
Compatibility and Stability of Palonosetron Hydrochloride with Four Neuromuscular Blocking Agents During Simulated Y-Site Administration Trusley Craig, Ben Michel, Kupiec Thomas C, Trissel Lawrence A Mar/Apr 2008 156-160 Buy
Chemical Stability of Perphenazine in Two Commercially Available Vehicles for Oral Liquid Dosage Forms Gupta Vishnu D Jul/Aug 2008 372-374 Buy