LP3 Network Free Webinar - Veterinary Compounding, A Customized Approach

Download in electronic PDF format for $25



Search the Complete Journal Archives

Physicochemical Stability of Compounded Creams Containing alpha-Hydroxy Acids

Author(s):  de Villiers Melgardt M, Narsai Kirti, van der Watt Jakkie G

Issue:  Jan/Feb 2000 - Compounding for Pain Management
View All Articles in Issue

Abstract:  The stability of creams containing the a-hydroxy acids (AHAs), lactic acid and glycolic acid, extemporaneously added to aqueous cream, BP or hydrophilic ointment, USP, and subjected to five freeze-thaw cycles ranging from –4 to 40°C was studied. The pH, viscosity, spreadibility, density, appearance and potency were measured after each freeze-thaw cycle. Compounding with hydrophilic ointment, USP produced the most stable creams; but the addition of the AHAs caused a significant decrease in preservative levels. The preservatives methylparaben and propylparaben were not hydrolyzed in the hydrophilic creams if the AHA was partially neutralized to a pH above 3.5.

Related Keywords: AHAs, alpha-hydroxy acids, appearance, creams, density, glycolic acid, lactic acid, pH, preservatives, spreadability, stability, viscosity

Related Categories: PEER-REVIEWED, STABILITIES, COMPATIBILITIES

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Physicochemical Stability of Compounded Creams Containing alpha-Hydroxy Acids de Villiers Melgardt M, Narsai Kirti, van der Watt Jakkie G Jan/Feb 2000 72-75 Buy
Acidifying Agents, Featured Excipient: Allen Loyd V Jr Jul/Aug 1999 309 Buy
Trichloroacetic Acid 20%, Salicylic Acid 20%, Lactic Acid 10% in Flexible Collodion Allen Loyd V Jr Sep/Oct 2015 410 Buy
Chemical Facial Peel Formulations: an Overview Levine Phillip J Sep/Oct 1999 375 Buy
Stability of Aminocaproic Acid Injection Admixtures in 5% Dextrose Injection and 0.9% Sodium Chloride Injection Zhang Yan-ping, Trissel Lawrence A Mar/Apr 1997 132-134 Buy
Basics of Compounding for the Treatment of Warts Allen Loyd V Jr Mar/Apr 2004 126 Buy
Lactic Acid 10% and Salicylic Acid 15% in Flexible Collodion Allen Loyd V Jr Mar/Apr 2004 127 Buy
Podophyllum, Lactic Acid, and Salicylic Acid Wart Mixture Allen Loyd V Jr May/Jun 2002 207 Buy
Alpha Hydroxy Acids Lotion Allen Loyd V Jr May/Jun 2004 213 Buy
Stability of Oral Liquid Dosage Forms of Ethacrynic Acid Gupta Vishnu D, Ling Jie May/Jun 2001 232-233 Buy