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Stability of Alatrofloxacin Mesylate in 5% Dextrose Injection and 0.45% Sodium-Chloride Injection

Author(s):  Gupta Vishnu D, Bailey RE

Issue:  Jan/Feb 2000 - Compounding for Pain Management
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Abstract:  A high-performance liquid chromatographic assay method for the quantitation of alatrofloxacin in intravenous (IV) admixtures has been developed. The method is accurate and precise, with a percent relative standard deviation of 1.2% based on five injections. The method is stability indicating since the product of decomposition, trovafloxacin, did not interfere with the assay procedure. The IV admixtures of alatrofloxacin (1.88 mg/mL) in 5% dextrose and 0.45% sodium-chloride injections were stable for at least nine days when stored at room temperature. The pH values of the admixtures did not change and they remained clear throughout this study.

Related Keywords: alatrofloxacin, dextrose, high performance liquid chromatography, injection, IV admixtures, pH, sodium chloride, stability, trovafloxacin

Related Categories: INFUSION, PEER-REVIEWED, STABILITIES, COMPATIBILITIES

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