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Room Temperature Stability of Injectable Succinylcholine Dichloride

Author(s):  Roy Julie J, Boismenu Daniel, Mamer Orval A, Nguyen Bao T, Forest Jean-Marc, Hildgen Patrice

Issue:  Jan/Feb 2008 - Compounding for Hospice and Cancer Patients
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Abstract:  The purpose of this study was to determine the room temperature stability over a period of several months of commercially available intravenous succinylcholine dichloride (Quelicin, 20 mg/mL) in vials. A previously validated electrospray tandem mass spectrometry method developed for the determination of succinylcholine dichloride in plasma was used. This method was based upon a stable isotope dilution assay using hexadeuterosuccinylcholine diiodide as the internal standard and was shown to be specific, sensitive, and reproducible. Calibration curves were plots of the ratios of intensities of the major product ions in the collision-induced dissociation spectrum for known concentration ratios of succinylcholine dichloride and hexadeuterosuccinylcholine diiodide in solutions. The concentration of succinylchloline dichloride was shown to decline linearly. After 1, 3, and 6 months at room temperature, the vial contents retained approximately 98%, 95%, and 90% of their initial concentrations, respectively. We sugge

Related Keywords: Julie J. Roy, BPharm, MSc, PhD, Daniel Boismenu, BSc, PhD, Orval A. Mamer, PhD, Bao T. Nguyen, BPharm, MSc, Jean-Marc Forest, BPharm, MSc, Patrice Hildgen, DPharm, PhD, succinylcholine dichloride, intravenous preparation, parenteral administration, drug stability, neuromuscular depolarizing blocking agent, endotracheal intubation, muscle relaxant, skeletal muscle relaxation

Related Categories: PARENTERALS, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, MUSCULOSKELETAL DISORDERS, NEUROLOGY

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