Medisca's Hair Care Compounding Solutions

Download in electronic PDF format for $25

Search the Complete Journal Archives

Levorphanol for the Treatment of Severe Chronic Pain

Author(s):  McNulty Jack P

Issue:  May/Jun 2007 - Pain Management
View All Articles in Issue

Abstract:  The search for an effective and affordable treatment for severe chronic pain, particularly neuropathic pain, has been elusive. The reluctance of many physicians to prescribe strong opioids for pain when other modalities have failed has resulted in the undertreatment of many patients. Levorphanol is 1 of 2 opioids that block N-methyl-Daspartate receptors. In this article, the mechanism of N-methyl-D-aspartate receptor activation is described, the efficacy of levorphanol in the treatment of severe chronic pain is examined, and the properties and clinical applications of that agent are reviewed. Other N-methyl-D-aspartate receptor antagonists are commented upon, and the outcome of treatment with levorphanol in chronic-pain patients is described in detail.

Related Keywords: Jack P. McNulty, MD, FACP, FAAHPM, levorphanol, N-methyl-D-aspartate receptor antagonist, NMDA blocker, pain control, pain management, analgesia, analgesics, neuropathic pain, neuralgia, neuropathy, drug interactions, dextromethorphan, ketamine, amantadine, methadone, memantine, opioid conversion


Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Levorphanol for the Treatment of Severe Chronic Pain McNulty Jack P May/Jun 2007 202-211 Buy
PostScription: Treatment of Chronic Pain with Methadone or Levorphanol McNulty Jack P Mar/Apr 2006 159-160 Buy
Levorphanol for Excruciating Pain from Oral Cancer: A Case Report McNulty Jack P May/Jun 2007 212-218 Buy
Update on Managing Neuropathic Pain McNulty Jack P, Muller George May/Jun 2009 182-190 Buy
Compounded Analgesic Therapy for Disorders of Movement: Arthritis, Neuropathic Pain, and Postpolio Syndrome Brown Scott, Erickson Brian, Muller George, Bryant-Snure Susan J, Mestayer Richard F III May/Jun 2010 182-192 Buy
Compounded Pain Formulations: What is the Evidence? Asbill Scott, Sweitzer Sarah M, Spigener Shuler, Romero-Sandoval Alfonso Jul/Aug 2014 278-286 Buy
Efficacy and Clinical Value of Commonly Used Ingredients in Pain Management Compounds: A Literature Review Beshay Sarah M, Rivera Gerard, Balthasar Jan, Florea Naomi Jul/Aug 2015 295-300 Buy
Topical Ketamine: A Review of the History, Mechanisms, Uses, Safety, and Future Rabi Joseph Mar/Apr 2016 107-113 Buy
Topical Medications for Orofacial Neuropathic Pain Bramwell Bethany L May/Jun 2010 200-203 Buy
Oral Methadone for Management of Regional Sympathetic Dystrophy Syndrome: A Case Revisited Vail Jane May/Jun 2007 187-192 Buy