Download in electronic PDF format for $25

Kalchem International - Chemicals and Compounding Supplies

Search the Complete Journal Archives

Stability of Oseltamivir in Various Extemporaneous Liquid Preparations

Author(s):  Ford Stephen M, Kloesel Lawson G, Grabenstein John D

Issue:  Mar/Apr 2007 - Diabetes
View All Articles in Issue

Abstract:  The purpose of this study was to determine the stability of oseltamivir, the active ingredient in Tamiflu, in contemporaneously compounded suspensions for a period of not less than 90 days. The suspension vehicles provided for the study were chosen because of ease of preparation, commercial availability, and palatability. Stability of the active ingredient was demonstrated for suspensions prepared in PCCA-Plus, PCCA Acacia, and 1% methylcellulose and was independent of storage temperature (tested temperatures were 2oC to 8oC and 25oC). A control sample of the commercial liquid form of Tamiflu was prepared, stored, and analyzed along with the samples prepared from the contents of capsules. There was no difference in the apparent stability of the two forms of the drug preparation.

Related Keywords: histamine 1 receptor inhibitor, H1 blocker, sedation, Stephen M Ford, PharmD, BCPS, BCOP, Lawson G Kloesel, RPh, BS Pharm, FIACP, John D Grabenstein, RPh, PhD, oseltamivir, antiviral agent, viral infection, virus, influenza, oral suspension vehicles, stability, storage, formulations


Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Stability of Oseltamivir in Various Extemporaneous Liquid Preparations Ford Stephen M, Kloesel Lawson G, Grabenstein John D Mar/Apr 2007 164-176 Buy
Wetting and/or Solubilizing Agents, Featured Excipient: Allen Loyd V Jr Jul/Aug 2001 310 Buy
Comparison of Rheological and Sedimentation Behavior of Commercially Available Suspending Vehicles for Oral Pharmaceutical Preparations Visser J Carolina, ten Seldam Inge E J, van der Linden Isabella J, Hinrichs Wouter L J, Veenendaal Reinier F H, Dijkers Eli C F, Woerdenbag Herman J May/Jun 2018 247-251 Buy
Oral Liquid Vehicles, Featured Excipient: Allen Loyd V Jr Jan/Feb 2001 65 Buy
Correcting Misconceptions about Compounding Bioidentical Hormones: A Review of the Literature Paoletti Jim, Kaul Monica, Kloesel Lawson G Jul/Aug 2007 269-272 Buy
Stability of Atenolol, Clonazepam, Dexamethasone, Diclofenac Sodium, Diltiazem, Enalapril Maleate, Ketoprofen, Lamotrigine, Penicillamine-D, and Thiamine in SyrSpend SF PH4 Oral Suspensions Polonini Hudson C, Loures Sharlene, Lima Luis Claudio, Ferreira Anderson O, Brandão Marcos Antônio F Mar/Apr 2016 167-174 Buy
Imatinib 40-mg/mL Oral Suspension Allen Loyd V Jr Nov/Dec 2016 510 Buy
Stability of Extemporaneously Prepared Hydroxycarbamide Oral Suspensions Kabiche Djamila, Balde Issa-Bella, Majoul Elyes, Kabiche Sofiane, Bourguignon Elodie, Fontan Jean-Eudes, Cisternino Salvatore, Schlatter Joel Mar/Apr 2017 160-163 Buy
Oseltamivir 12-mg/mL Oral Suspension Allen Loyd V Jr Jul/Aug 2007 332 Buy
Profile of a Practice: Stephen J. Newton, RPh, and PharmaTech Services, Inc., Avon, Colo. Allen Loyd V Jr Mar/Apr 2004 107-109 Buy