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Five-Day Stability of Vinorelbine in 5% Dextrose Injection and in 0.9% Sodium Chloride Injection at Room Temperature
Author(s): Lieu Cynthia L, Chin Alfred, Gill Mark A
Issue: Jan/Feb 1999 - Dental Compounding
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Abstract: The stability of vinorelbine tartrate in 5% dextrose injection or 0.9% sodium chloride injection stored in polyvinyl chloride minibags was studied. Vinorelbine was diluted to concentrations of 0.5 mg/mL or 2 mg/mL in the above vehicles, and the solution was placed at room temperature and exposed to constant fluorescent lighting. Three bags were prepared for each concentration and solution and each bag was assayed for vinorelbine concentration by stability-indicating high-performance liquid chromatography at 0, 24, 48, 96 and 120 hours. Each solution was inspected for clarity, color and precipitation. Throughout the study, the mean concentration of vinorelbine remaining was more than 94% of the initial concentration in both vehicles. No precipitation, color change or haziness was seen. Vinorelbine, at concentrations of 0.5 mg/mL or 2 mg/mL in 5% dextrose injection or 0.9% sodium chloride injection, was stable for at least 120 hours at room temperature under fluorescent lighting.
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