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Y-Site Stability of Fosphenytoin and Sodium Phenobarbital

Author(s):  English Brett A, Riggs Robert M, Webster Andrew A, Benner Kimberly W

Issue:  Jan/Feb 1999 - Dental Compounding
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Abstract:  Fosphenytoin and sodium phenobarbital in 0.9% sodium chloride injection were analyzed in a simulated Y-site admixture. Each drug was analyzed for stability by high-pressure liquid chromatography (HPLC) from three simulated Y-site samples over an eight-hour period. The HPLC assay results indicate that both fosphenytoin and sodium phenobarbital are stable together at a Y site over an eight-hour period. In addition, there was no change in sample clarity or pH over the same period. The results indicate that, when medically necessary, fosphenytoin and sodium phenobarbital in 0.9% sodium chloride injection can be administered via the same intravenous line.


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