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Chemical Stability of Metoclopramide Hydrochloride Injection Diluted with 0.9% Sodium Chloride Injection in Polypropylene Syringes at Room Temperature

Author(s):  Gupta Vishnu D

Issue:  Jan/Feb 2005 - Sterile Preparations
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Abstract:  The stability of metoclopramide hydrochloride (0.5 mg/mL) in 0.9% sodium chloride injection in polypropylene syringes was studied at 25 degrees C, using a stability-indicating high-performance liquid chromatographic assay method. The concentrations of the drug were directly related to peak heights, and the percent relative standard deviation based on five injections was 1.4. The drug decomposed when treated with sodium hydroxide or hydrochloric acid, and the products of decomposition did not interfere with the assay procedure. The injection did not lose any potency after 21 days of storage at 25 degrees C, and the pH value of 5.0 did not change. The physical appearance of the injection remained clear throughout the study period.

Related Keywords: Vishnu D. Gupta, PhD, metoclopramide hydrochloride, stability, gastrointestinal motility, prokinetic, children

Related Categories: GASTROENTEROLOGY, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, ENDOCRINOLOGY/HORMONES/ MENOPAUSE/ANDROPAUSE

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