Download in electronic PDF format for $35

Search the Complete Journal Archives

A Need for Propylene Glycol-Free Ascorbic Acid Oral Liquid

Author(s):  McElhiney Linda F

Issue:  Nov/Dec 2004 - Endotoxin
View All Articles in Issue

Abstract:  Most commercially available oral liquid preparations of ascorbic acid contain propylene glycol. At high doses, this common food and drug additive is know to increase the risk of serum hyperosmolality, with a marked osmolar gap, lactic acidosis, seizures, and cardiac arrhythmias. This is a particular danger in children. Concern about propylene glycol toxicity prompted the World Health Organization to establish a maximum daily dose of 25 mg/kg/day, but the toxic dose is not known. A stable ascorbic acid preparation can be formulated without propylene glycol. A formula and method are provided.

Related Keywords: Linda F. McElhiney, PharmD, RPh, burns, burn units, vitamin C, children, propylene glycol, toxic effects, liquid formulations, adverse effects, ascorbic acid syrup, formulation: ascorbic acid 100-mg/mL syrup


Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
A Need for Propylene Glycol-Free Ascorbic Acid Oral Liquid McElhiney Linda F Nov/Dec 2004 458-460 Buy
Basics of Compounding for Cough Allen Loyd V Jr Nov/Dec 2004 462-465 Buy
Ascorbic Acid 250-mg/mL Injection Allen Loyd V Jr May/Jun 2012 240 Buy
L-Arginine and Ascorbic Acid for Diabetic Foot Ulcers Gorman Shellie Mar/Apr 2000 94-96 Buy
Compounding in the Pharmacy Curriculum: Beyond the Basics Hinkle Amanda R, Newton Gail D May/Jun 2004 181-185 Buy
Acidifying Agents, Featured Excipient: Allen Loyd V Jr Jul/Aug 1999 309-310 Buy
Trichloroacetic Acid 20%, Salicylic Acid 20%, Lactic Acid 10% in Flexible Collodion Allen Loyd V Jr Sep/Oct 2015 410 Buy
Gastrointestinal Mucositis: Focus on the Treatment of the Effects of Chemotherapy and Radiotherapy on the Rectum Zur Eyal Mar/Apr 2012 117-124 Buy
Unit Dose Packaging and Repackaging of Solid and Liquid Dosage Forms in an Institutional Setting McElhiney Linda F Jan/Feb 2010 32-38 Buy
Burning Mouth Syndrome: A Discussion of a Complex Pathology Zur Eyal May/Jun 2012 196-205 Buy