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Chemical Stability of Terbutaline Sulfate Injection After Diluting With Normal Saline When Stored at Room Temperature in Polyvinylchloride Bags

Author(s):  Gupta Vishnu D

Issue:  Sep/Oct 2004 - Topical Treatments in Wound Healing
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Abstract:  The stability of terbutaline sulfate (0.1 mg/mL) in 0.9% sodium cloride injection was studied at 25°C when stored in polyvinylchloride bags, using a stabilityindicating high-performance liquid chromatographic assay method. The concentrations of the drug were directly related to peak heights, and percent relative standard deviation based on five injections was 1.0. The drug decomposed when boiled after adding sodium hydroxide, and the products of decomposition did not interfere with the assay procedure. The injection did not lose any potency after 23 days of storage at 25°C, and the pH value of 4.3 did not change. The physical appearance of the injection remained clear throughout the study period.

Related Keywords: Vishnu D. Gupta, PhD, HPLC, PVC

Related Categories: INFUSION, PEER-REVIEWED, STABILITIES, COMPATIBILITIES

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