LP3 Network Free Webinar - Veterinary Compounding, A Customized Approach

Download in electronic PDF format for $25



Search the Complete Journal Archives

Compatibility and Stability of Aloxi (Palonosetron Hydrochloride) Admixed With Dexamethasone Sodium Phosphate

Author(s):  Trissel Lawrence A, Zhang Yanping

Issue:  Sep/Oct 2004 - Topical Treatments in Wound Healing
View All Articles in Issue

Abstract:  The purpose of this study was to evaluate the physical and chemical stability of palonosetron hydrochloride 0.25 mg admixed with dexamethasone (as sodium phosphate) 10 mg or 20 mg in 5% dextrose injection or 0.9% sodium chloride injection in polyvinylchloride minibags, and also admixed with dexamethasone (as sodium phosphate) 3.3 mg in 5% dextrose injection or 0.9% sodium chloride injection in polypropylene syringes, at 4°C stored in the dark for 14 days, and at 23°C exposed to normal laboratory fluorescent light over 48 hours.

Test samples of palonosetron hydrochloride 5 µg/mL with dexamethasone (as sodium phosphate) 0.2 mg/mL and also 0.4 mg/mL were prepared in polyvinylchloride minibags of each infusion solution. Additionally, palonosetron hydrochloride 25 µg/mL with dexamethasone (as sodium phosphate) 0.33 mg/mL in each infusion solution were prepared as 10 mL of test solution in 20-mL polypropylene syringes. Evaluations for physical and chemical stability were performed on samples taken initially and after 1, 3, 7 and 14 days of storage at 4°C and after 1, 4, 24 and 48 hours at 23°C. Physical stability was assessed using visual observation in normal room light and using a high-intensity monodirectional light beam. In addition, turbidity and particle content were measured electronically. Chemical stability of the drug was evaluated by using a stabilityindicating high-performance liquid chromatographic analytical technique.

All samples were physically compatible throughout the study. The solutions remained clear and showed little or no change in particulate burden and haze level. Additionally, little or no loss of palonosetron hydrochloride and dexamethasone occurred in any of the samples at either temperature throughout the entire study period.

Admixtures of palonosetron hydrochloride with dexamethasone sodium phosphate in 5% dextrose injection or in 0.9% sodium chloride injection packaged in polyvinylchloride minibags or in polypropylene syringes were physically compatible and chemically stable for at least 48 hours at room temperature and for 14 days under refrigeration.

Related Keywords: Lawrence A. Trissel, BS, RPh, FASHP, Yanping Zhang, BS, HPLC, concentration, Polyvinylchloride (PVC), dextrose, sodium chloride

Related Categories: INFUSION, PEER-REVIEWED, STABILITIES, COMPATIBILITIES

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Compatibility and Stability of Aloxi (Palonosetron Hydrochloride) Admixed With Dexamethasone Sodium Phosphate Trissel Lawrence A, Zhang Yanping Sep/Oct 2004 398-403 Buy
Extended Stability of Oxytocin in Common Infusion Solutions Trissel Lawrence A, Zhang Yanping, Douglass Kate, Kastango Eric Mar/Apr 2006 156-158 Buy
Temozolomide Stability in Extemporaneously Compounded Oral Suspensions Trissel Lawrence A, Zhang Yanping, Koontz Susannah E Sep/Oct 2006 396-399 Buy
Long-Term Stability of Trimix: A Three-Drug Injection Used to Treat Erectile Dysfunction. Trissel Lawrence A, Zhang Yanping May/Jun 2004 231-235 Buy
Physical and Chemical Stability of Palonosetron Hydrochloride with Fluorouracil and with Gemcitabine Hydrochloride during Simulated Y-site Administration Trissel Lawrence A, Zhang Yanping Jul/Aug 2005 320-322 Buy
Compatibility of Micafungin Injection with Other Drugs During Simulated Y-Site Co-administration Trusley Craig, Kupiec Thomas C, Trissel Lawrence A May/Jun 2006 230-233 Buy
Physical and Chemical Stability of Palonosetron Hydrochloride with Dacarbazine and with Methylprednisolone Sodium Succinate During Simulated Y-Site Administration Trissel Lawrence A, Xu Quanyun A, Zhang Yanping May/Jun 2006 234-236 Buy
Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration Ben Michel, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A Nov/Dec 2007 520-524 Buy
Physical and Chemical Stability of Trepostinil Sodium Injection Packaged in Plastic Syringe Pump Reservoirs. Xu Quanyun A, Trissel Lawrence A, Pham Lien May/Jun 2004 228-230 Buy
Stability of Ampicillin Sodium, Nafcillin Sodium, and Oxacillin Sodium in AutoDose Infusion System Bags Zhang Yanping, Trissel Lawrence A May/Jun 2002 226-229 Buy