LP3 Network Free Webinar - Veterinary Compounding, A Customized Approach

Download in electronic PDF format for $25



Search the Complete Journal Archives

Enhanced Release of Diazepam from Hollow-Type Suppositories

Author(s):  Kaewnopparat N, Kaewnopparat S, Rojanarat W, Ingkatawornwong S

Issue:  Jul/Aug 2004 - Wound Care
View All Articles in Issue

Abstract:  The objective of this study was to develop a rapid-release diazepam suppository. Four kinds of diazepam suppositories were formulated: (1) a conventional suppository with Witepsol H-15 as a base, (2) a conventional suppository with mixed polyethylene glycols as a base, (3) a hollow-type suppository with Witepsol H-15 as a base that contained diazepam solution in its cavity and (4) a hollow-type suppository with Witepsol H-15 as a base that contained diazepam powder in its cavity. The result of the differential scanning calorimetry thermograms indicated that diazepam dissolved in Witepsol base had strong affinity to the lipophilic base while diazepam dispersed in polyethylene glycol base was still in the crystalline form. The release study of prepared suppositories showed that the release of diazepam from suppository 1 and suppository 4 was very slow. The diazepam released from suppository 2 after 5 minutes was about 30%. The diazepam released from suppository 3 after 5 minutes was about 85%, which was significantly faster than that of the other three formulations (1, 2 and 4). The hollow-type suppository that contained diazepam solution was found to be the most effective rapid-release formulation.

Related Keywords: Diazepam, enhanced release, in hollow suppositories, Ingkatawornwong S, MSPharm, Kaewnopparat N, MSPharm, Kaewnopparat S, PhD,BioPharm, Rojanarat W, BSPharm, Suppositories, diazepam compounding of

Related Categories: MENTAL HEALTH, PEER-REVIEWED

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Enhanced Release of Diazepam from Hollow-Type Suppositories Kaewnopparat N, Kaewnopparat S, Rojanarat W, Ingkatawornwong S Jul/Aug 2004 310-312 Buy
Compounded Suppositories and Pharmaceutical Care Duncan-Hewitt Wendy, Rains John Mar/Apr 1997 93-99 Buy
Preparation and Evaluation of Sustained Drug Release from Pluronic Polyol Rectal Suppositories Anderson Derick, Amiji Mansoor M May/Jun 2001 234-237 Buy
Compounding in the Pharmacy Curriculum: Beyond the Basics Hinkle Amanda R, Newton Gail D May/Jun 2004 181 Buy
Isoniazid Release from Suppositories Compounded with Selected Bases Hudson Kristofer C, Asbill C Scott, Webster Andrew A Sep/Oct 2007 433-437 Buy
Basics of Compounding: Compounding Suppositories Part 2 Allen Loyd V Jr Sep/Oct 2000 371 Buy
Basics of Compounding: Compounding Suppositories: Part I - Theoretical Considerations Allen Loyd V Jr Jul/Aug 2000 289 Buy
Gentian Violet Vaginal Suppositories Allen Loyd V Jr Nov/Dec 2009 556 Buy
Diazepam 5-mg/mL Injection Allen Loyd V Jr Mar/Apr 2003 135 Buy
Tips and Hints: Powders, Capsules, Tablets, Suppositories, and Sticks Allen Loyd V Jr Jan/Feb 2014 42-45 Buy