Introducing Medisca Nutraceuticals

Download in electronic PDF format for $25



Search the Complete Journal Archives

Chemical Stability of Phenylephrine HCl After Reconstitution in 0.9% Sodium Chloride Injection for Infusion

Author(s):  Gupta Vishnu D

Issue:  Mar/Apr 2004 - Overview of USP Chapter <797>
View All Articles in Issue

Abstract:  The chemical stability of phenylephrine hydrochloride (0.2 and 0.1 mg/mL) in 0.9% sodium chloride injection stored in polyvinyl chloride bags was studied at 25°C by means of a stability-indicating high-performance liquid chromatographic assay method. The concentrations of the drug were directly related to peak heights, and the percent relative standard deviation based on five injections was 1.0. The excipients present in the injection did not interfere with the assay procedure. The products of decomposition separated from the intact drug. At both concentrations (0.2 and 0.1 mg/mL), the loss in potency was less than 1.0% after 14 days of storage at room temperature. The pH value of the 0.2-mg/mL injection decreased from 4.3 to 4.0 after 14 days of storage, and the pH value of the 0.1-mg/mL injection decreased from 4.4 to 4.2. The physical appearance of the injection did not change.

Related Keywords: Gupta, Vishnu D, PhD, Phenylephrine hydrochloride, reconstituted for infusion, chemical stability of

Related Categories: INFUSION, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, STERILE PREPARATIONS

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Chemical Stability of Phenylephrine HCl After Reconstitution in 0.9% Sodium Chloride Injection for Infusion Gupta Vishnu D Mar/Apr 2004 153-155 Buy
Chemical Stability of Brompheniramine Maleate in an Oral Liquid Dosage Form Gupta Vishnu D, Gupta Vikas S Jan/Feb 2011 78-80 Buy
Chemical Stability of Amitriptyline Hydrochloride in Oral Liquid Dosage Forms Gupta Vishnu D Sep/Oct 2009 445-446 Buy
Chemical Stability of Cyproheptadine Hydrochloride in an Oral Liquid Dosage Form Gupta Vishnu D Jul/Aug 2007 347-348 Buy
Chemical Stability of Tramadol Hydrochloride Injection Gupta Vishnu D Mar/Apr 2008 161-162 Buy
Chemical Stability of Naltrexone Hydrochloride Injection Gupta Vishnu D May/Jun 2008 274-275 Buy
Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Clonidine Hydrochloride Packaged in Plastic Syringes Xu Quanyun A, Trissel Lawrence A, Pham Lien Jan/Feb 2002 66-69 Buy
Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Bupivacaine Hydrochloride Packaged in Plastic Syringes Trissel Lawrence A, Xu Quanyun A, Pham Lien Jan/Feb 2002 70-73 Buy
Chemical Stability of Cefazolin Sodium after Reconstituting in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use Gupta Vishnu D Mar/Apr 2003 152-154 Buy
Stability and Compatibility of Reconstituted Caspofungin in Select Elastomeric Infusion Device Tsiouris Maria, Ulmer Marisa, Yurcho James F, Hooper Kevin L, Gui Min Sep/Oct 2010 436-439 Buy