LP3 Network Free Webinar - Veterinary Compounding, A Customized Approach

Download in electronic PDF format for $25



Search the Complete Journal Archives

Containment of Hazardous Particulates in the Compounding Pharmacy

Author(s):  Allen Loyd V Jr

Issue:  Jul/Aug 2003 - After the Women's Health Initiative Trial
View All Articles in Issue

Abstract:  This article describes the experience of Ray Moreno, RPh, FIACP, a compounding pharmacist/pharmacy owner since 1982. When a technician developed a small benign lump in a breast after the pharmacy had begun compounding more bioidentical hormone preparations, he began to look for additional ways to protect his employees. Although gloves were worn during compounding, Moreno became concerned about airborne particulates. He then provided technicians with surgical masks and began investigating fume hoods, which still did not appear to be adequate protection. Next he investigated hood-type air-filtration devices. He invested in a chemo hood and other protective devices but still was not confident they provided enough protection. He evaluated his employees by means of saliva testing to determine staff levels of estrogen, estradiol and testosterone over an 18-month period, with increasing protection for employees during compounding, and was dismayed to find that they had elevated hormone levels. He then contacted Germfree Laboratories, Inc., a Florida company specializing in laminar flow equipment, to develop special equipment. After company experts visited the pharmacy and talked with Moreno, they designed a negative-pressure particulate containment hood that covers the work space and is 2 feet above the work surface. The hood, designed for high-efficiency particulate air filter testing and certification, has the inward face velocity of a class I biological safety cabinet. Everything needed for compounding is contained within the hood. Further refinements of procedures, in addition to use of the hood, resulted in lowering of employee hormone levels to the normal range. Moreno continues to work with the company to design a laminar-flow glovebox for compounding.

Related Keywords: Containment, of hazardous particulates during compounding, Hazards, minimizing during compounding, Safety, during compounding, Toxic substances, minimizing exposure during compounding

Related Categories: LEGAL, STERILE PREPARATIONS, SUPPORT

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Containment of Hazardous Particulates in the Compounding Pharmacy Allen Loyd V Jr Jul/Aug 2003 281-285 Buy
Compounding in the Pharmacy Curriculum: Beyond the Basics Hinkle Amanda R, Newton Gail D May/Jun 2004 181 Buy
Current Topical Treatments in Wound Healing - Part 1 Helmke Christopher D Jul/Aug 2004 269 Buy
PostScription: Guidance to Achieve Accreditation from the Pharmacy Compounding Accreditation Board Pharmacy Compounding Accreditation Board Sep/Oct 2010 440-441 Buy
An Ounce of Prevention: Controlling Hazards in Extemporaneous Compounding Practices Kastango Eric S, Trissel Lawrence A, Bradshaw Brian D Sep/Oct 2003 401 Buy
The Role of Compounding in Closing Therapeutic Gaps--Abstracts from FIP 2013 Lutz Eugene, Pauletti Giovanni, Carvalho Maria, Davidson Gigi, Ashworth Lisa, Subramaniam Vaiyapuri, LlambĂ­ Francesc Jan/Feb 2014 6-12 Buy
Product Containment in the Compounding Laboratory Vidrine Eric May/Jun 2003 213 Buy
Basics of Compounding for Cold Sores or Fever Blisters Allen Loyd V Jr May/Jun 2004 206 Buy
Prophylaxis Against Exposure to Bloodborne Pathogens During Compounding Williams Angie, Mixon William Jan/Feb 2010 14-18 Buy
Minimizing the Risk of Teratogenic Substance Exposure for Pregnant Compounding Pharmacists Paoletti James E, Benavides Tomas J Nov/Dec 1998 414-415 Buy