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Sensitization Therapy for Warts

Author(s):  Kuntz Rachael

Issue:  Jul/Aug 2003 - After the Women's Health Initiative Trial
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Abstract:  This discussion of warts focuses on treatment (topical treatment, cryosurgery, laser therapy and electrotherapy), immunotherapy, (dinitrochlorobenzene, diphencyprone and squaric acid dibutylester) and applications in compounding. Tables provide information as to major wart classifications and their descriptions, topical agents used in the treatment of warts, formulations for sensitization therapy for warts (Dinitrochlorobenzene 0.5% to 2.0% in Acetone, Dinitrochlorobenzene 0.1% to 1% in Hydrophilic Petrolatum, Diphenylcyclopropenone 0.01% in Acetone, and Squaric Acid Dibutyl Ester 0.03% in Acetone) and Formulations for Topical Treatment of Warts (Cantharidin 0.7% Topical, Fluorouracil 5% Gel, Podophyllum 25% in Compound Tincture of Benzoin, Podophyllum 1% and Salicylic Acid 3% in Flexible Collodion, and Salicylic Acid 40% Ointment). The author concludes immunotherapy with agents such as those discussed in this article offers an alternative to traditional treatments that can take months to work or be painful. Since dinitrochlorobenzene is mutagenic, the author recommends only the other two immunotherapeutic agents for use; although studies proving their safety and efficacy are limited, available evidence suggests that immunotherapy can cure warts in a timely manner and often with little pain or irritation.

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Related Categories: DERMATOLOGY

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