LP3 Network Free Webinar - Veterinary Compounding, A Customized Approach

Download in electronic PDF format for $25



Search the Complete Journal Archives

Stability of Lidocaine Hydrochloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes

Author(s):  Storms Meredith L, Stewart James T, Warren Flynn W

Issue:  Sep/Oct 2002 - Veterinary Compounding
View All Articles in Issue

Abstract:  The stability of 20 mg/mL lidocaine hydrochloride injection in 12-mL polypropylene syringes stored at ambient temperature and at 4°C for up to 90 days was investigated. A highperformance liquid chromatographic stability-indicating assay was used to determine the concentration level of lidocaine hydrochloride injection at 0, 1, 4, 7, 15, 30, 45, 60, and 90 days after preparation of the syringes. Methylparaben, which was added as a preservative, did not interfere with the assay. The injections in plastic syringes were stable for up to 90 days at both ambient temperature and at 4°C. The pH of lidocaine hydrochloride injection did not change appreciably during the 90-day study period. These data indicate the stability of lidocaine hydrochloride under the storage conditions investigated in this study.

Related Keywords: Lidocaine hydrochloride injection, effect of temperature on stability of, Lidocaine hydrochloride injection, stability of during storage

Related Categories: PEER-REVIEWED, STABILITIES, COMPATIBILITIES

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Stability of Lidocaine Hydrochloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes Storms Meredith L, Stewart James T, Warren Flynn W Sep/Oct 2002 388-390 Buy
Stability of Aminocaproic Acid Injection Admixtures in 5% Dextrose Injection and 0.9% Sodium Chloride Injection Zhang Yan-ping, Trissel Lawrence A Mar/Apr 1997 132-134 Buy
Stability of Neostigmine Methylsulfate Injection at Ambient Temperature and 4°C in Polypropylene Syringes Storms Meredith L, Stewart James T, Warren Flynn W Nov/Dec 2002 475-477 Buy
pH Stability of Injectable Fentanyl, Bupivacaine, or Clonidine Solution or a Ternary Mixture in 0.9% Sodium Chloride in Two Types of Polypropylene Syringes Jappinen Annaliisa L, Kokki H, Rasi A S, Naaranlahti Toivo J Nov/Dec 2002 471-474 Buy
Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Clonidine Hydrochloride Packaged in Plastic Syringes Xu Quanyun A, Trissel Lawrence A, Pham Lien Jan/Feb 2002 66-69 Buy
Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Bupivacaine Hydrochloride Packaged in Plastic Syringes Trissel Lawrence A, Xu Quanyun A, Pham Lien Jan/Feb 2002 70-73 Buy
Chemical Stability of Diphenhydramine Hydrochloride from an Elixir and Lidocaine Hydrochloride from a Viscous Solution when Mixed Together Gupta Vishnu D May/Jun 2006 237-239 Buy
Lidocaine Hydrochloride 1.82% Buffered Injection Allen Loyd V Jr Nov/Dec 2007 511 Buy
Lidocaine Hydrochloride 1% Injection Allen Loyd V Jr May/Jun 2014 237 Buy
Effect of Freezing, Long-Term Storage and Microwave Thawing on the Stability of Tramadol in 5% Dextrose Infusion in Polyvinyl Chloride Bags Lebrun John, Hecq Jean-Daniel, Vanbeckbergen Danielle, Jamart Jacques, Galanti Laurence M Mar/Apr 2004 156-159 Buy