LP3 Network Free Webinar - Veterinary Compounding, A Customized Approach

Download in electronic PDF format for $25



Search the Complete Journal Archives

Pharmaceutical Profile of Vitamin C Tablets and Capsules

Author(s):  Al-Achi Antoine, Greenwood Robert, Nzazi Guy

Issue:  Sep/Oct 2000 - Compounding for Immune System Disorders
View All Articles in Issue

Abstract:  This study examines the pharmaceutical profile of 3 brands of immediate-release vitamin C tablets (500 mg) available commercially in North Carolina and 3 batches of vitamin C capsules (500 mg) extemporaneously prepared in our laboratory. Several pharmaceutical tests were performed on 3 bottles from 3 different brands of immediaterelease vitamin C tablets that were purchased from local stores. The brands were compared with respect to thickness, weight variation, hardness, dissolution, disintegration time, and content uniformity tests. The results showed differences among the brands in thickness, weight variation, hardness, and disintegration time. Bottles from 2 of the brands showed a significant difference in some of their test profiles. Weight variation, dissolution, and content uniformity were determined for the prepared capsules. The average weight of the capsules from the 3 batches was similar and was slightly below 700 mg. The content of ascorbic acid in the capsules ranged from 95.4% to 113.5% of the labeled amount, with an overall average of 107.5% for the 3 batches. Dissolution tests on the capsules revealed that the release of vitamin C was complete within a 1-hour period, which is similar to that seen with the commercial tablets. These results make it advisable for pharmacists, when counseling patients, to have this variability among commercial brands of vitamin C in mind.

Related Keywords: Vitamin C

Related Categories: NUTRITION AND NUTRICEUTICALS, PEER-REVIEWED

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Vitamins: Therapy or Hype Wynn Tom, Hoffrogge Zach Jan/Feb 2012 17-21 Buy
Vitamin A Suppository Allen Loyd V Jr Jul/Aug 2008 363 Buy
Marketing Vitamins, Minerals, and Other Nutrients Kress Robert B Jan/Feb 2011 44-47 Buy
Pharmaceutical Profile of Vitamin C Tablets and Capsules Al-Achi Antoine, Greenwood Robert, Nzazi Guy Sep/Oct 2000 400-403 Buy
Vitamin B12 1-mg/mL Nasal Spray Allen Loyd V Jr May/Jun 2002 208 Buy
Zinc, Magnesium, Caldium and Vitamin D3 Oral Liquid Glasnapp Andrew Jul/Aug 2003 291 Buy
Natural-Product Therapies for Treating Diabetic Neuropathy Anderson Constance Mar/Apr 2000 98 Buy
Cyanocobalamin, Choline, and Niacinamide Injection Allen Loyd V Jr Jul/Aug 2010 339 Buy
Riboflavin 5-mg/mL Oral Suspension Allen Loyd V Jr Jul/Aug 2011 343 Buy
Complementary Medicine - A Wellness Plan for People with Diabetes Singer Debra Mar/Apr 2000 101 Buy