LP3 Network Free Webinar - Veterinary Compounding, A Customized Approach

Download in electronic PDF format for $25



Search the Complete Journal Archives

Stability of Lisinopril Syrup (2 mg/mL) Extemporaneously Compounded from Tablets

Author(s):  Rose Deidra J, Webster Andrew A, English Brett A, McGuire J Michael

Issue:  Sep/Oct 2000 - Compounding for Immune System Disorders
View All Articles in Issue

Abstract:  The stability of lisinopril syrup (2 mg/mL) extemporaneously compounded from tablets was investigated. Zestril® tablets (Lot CSC201, Zeneca Pharmaceuticals, Wilmington, Del) were crushed, dissolved in water, filtered, and diluted with syrup NF to a final nominal concentration of 2 mg/mL. The solution was then equally divided among amber-colored prescription bottles and was stored at 5°C and 23°C. During the 30-day study period, samples were extracted by means of a water:methanol mix, and the concentration of lisinopril was determined by a stability-indicating, highperformance liquid chromatography assay procedure. Stability was also determined by pH measurements and visual inspection for color or clarity change. Over the 30- day study period, the percentage of the initial lisinopril concentration remained between 99.42% ± 0.19% and 95.68% ± 1.5% for the 5°C samples and 98.83% ± 0.46% and 96.48% ± 0.62% for the 23°C samples.

Related Keywords: lisinopril syrup, stability, liquid lisinopril, storage

Related Categories: PEER-REVIEWED, STABILITIES, COMPATIBILITIES

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Stability of Lisinopril Syrup (2 mg/mL) Extemporaneously Compounded from Tablets Rose Deidra J, Webster Andrew A, English Brett A, McGuire J Michael Sep/Oct 2000 398-399 Buy
Lisinopril 1-mg/mL Oral Liquid Allen Loyd V Jr Jul/Aug 2006 302 Buy
The Stability of Lisinopril as an Extemporaneous Syrup Webster Andrew A, English Brett A, Rose Deidra J Sep/Oct 1997 352-353 Buy
Lisinopril 1-mg/mL, Sodium Citrate, and Citric Acid Oral Liquid Allen Loyd V Jr Sep/Oct 2006 386 Buy
Stability of Allopurinol, Amitriptyline Hydrochloride, Carbamazepine, Domperidone, Isoniazid, Ketoconazole, Lisinopril, Naproxen, Paracetamol (Acetaminophen), and Sertraline Hydrochloride in SyrSpend SF PH4 Oral Suspensions Polonini Hudson C, Loures Sharlene, de Araujo Edson Peter, Brandão Marcos Antônio F, Ferreira Anderson O Sep/Oct 2016 426-434 Buy
pH Stability of Injectable Fentanyl, Bupivacaine, or Clonidine Solution or a Ternary Mixture in 0.9% Sodium Chloride in Two Types of Polypropylene Syringes Jappinen Annaliisa L, Kokki H, Rasi A S, Naaranlahti Toivo J Nov/Dec 2002 471-474 Buy
Stability of Oseltamivir Phosphate in SyrSpend SF, Cherry Syrup, and SyrSpend SF (For Reconstitution) Voudrie Mark A II, Allen D Brett Jan/Feb 2010 82-85 Buy
Oral Liquid Vehicles, Featured Excipient: Allen Loyd V Jr Jan/Feb 2001 65 Buy
Stability of Verapamil Hydrochloride in SyrSpend SF Compared to Sorbitol Containing Syrup and Suspending Vehicles Voudrie Mark A, Alexander Bridget, Allen D Brett May/Jun 2011 255-258 Buy
Effect of Freezing, Long-Term Storage and Microwave Thawing on the Stability of Tramadol in 5% Dextrose Infusion in Polyvinyl Chloride Bags Lebrun John, Hecq Jean-Daniel, Vanbeckbergen Danielle, Jamart Jacques, Galanti Laurence M Mar/Apr 2004 156-159 Buy