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The Stability of Lisinopril as an Extemporaneous Syrup

Author(s):  Webster Andrew A, English Brett A, Rose Deidra J

Issue:  Sep/Oct 1997 - Home Health Care
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Abstract:  The stability of lisinopril as an extemporaneous syrup compounded from powder was studied. The lisinopril syrup (2 mg/mL) was prepared by incorporating lisinopril powder dissolved in water into simple syrup. Samples of the syrup were stored in amber-colored plastic bottles at 5 and 23°C. At various times during the 30-day study period, the concentration of lisinopril was determined by a stability-indicating high performance liquid chromatography assay procedure. Samples were also visually inspected for color and clarity. Over the 30- day study period, the percentage of the initial concentration remained between 97.46% and 100.54% for the 23°C samples and 98.15% and 100.74% for the 5°C samples.


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