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Chemical Stability of Amiodarone Hydrochloride in Intravenous Fluids

Author(s):  Pramar Yashoda V

Issue:  Sep/Oct 1997 - Home Health Care
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Abstract:  The chemical stability of amiodarone hydrochloride in two intravenous (IV) fluids, 5% dextrose injection and 0.9% sodium chloride injection, was studied. Drug degradation was monitored using a stability-indicating, high-performance liquid chromatography assay method. The admixtures of amiodarone in the two IV fluids were found to be stable for 32 days when refrigerated (5°C), and also at room temperature (25°C). All solutions remained clear during this period. The recommendations from the manufacturer are conservative. The admixtures are apparently physically and chemically stable for more than 24 hours, provided they are protected from microbiological contamination. However at 40°C, significant degradation was observed after 18 days; and the solutions turned cloudy. Precautions must be taken to prevent temperature elevation during storage.

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