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Stability of Clonazepam Suspension in HSC Vehicle

Author(s):  Roy Julie J, Besner Jean-Guy

Issue:  Nov/Dec 1997 - Diverse Ambulatory Patients
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Abstract:  The stability of clonazepam as an extemporaneous suspension compounded from tablets was studied. The clonazepam suspension (0.1 mg/mL) was prepared by incorporating pulverized 0.5- mg clonazepam tablets into the suspending Hospital for Sick Children (HSC) Vehicle containing simple syrup and methylcellulose.

This vehicle is also prepared extemporaneously. A clonazepam suspension and a clonazepam solution, both prepared in HSC Vehicle, were analyzed at various times during the 60-day study period against a clonazepam standard acetonitrile solution stored in glass.

These preparations using HSC Vehicle were stored at 4°C in a polyvinyl chloride (PVC) amber-colored plastic bottle. At various times during the 60-day study period, three samples from each bottle were removed and the concentration of clonazepam determined by a high-performance liquid chromatography assay procedure.

This stability study demonstrates that storage of clonazepam suspension is safe for at least 60 days in a PVC bottle at 4°C, while the HSC solution rapidly loses the active ingredient by adsorption onto the plastic matrix due to the immediate availability towards the PVC.

Related Keywords: benzodiazepine


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