Logo - International Journal of Pharmaceutical Compounding

Physical and Chemical Stability of Palonosetron Hydrochloride with Fluorouracil and with Gemcitabine Hydrochloride during Simulated Y-site Administration

Author(s):  Trissel Lawrence A, Zhang Yanping

Issue:  Jul/Aug 2005 - Human Hormone Replacement Therapy
View All Articles in Issue

Abstract:  The objective of this study was to evaluate the physical and chemical stability of undiluted palonosetron 50 µg/mL as the hydrochloride with fluorouracil 16 mg/mL, and with gemcitabine 10 mg/mL as the hydrochloride, in 5% dextrose injection during simulated Y-site administration. Triplicate test samples were prepared by admixing 7.5 mL of palonosetron hydrochloride with 7.5 mL of the fluorouracil and gemcitabine hydrochloride admixtures. Physical stability was assessed by using a multistep evaluation procedure that included both turbidimetric and particulate measurements as well as visual inspection. Chemical stability was assessed by using stability-indicating high-performance liquid chromatographic analytical techniques that determined drug concentrations. Evaluations were performed initially upon mixing and 1 and 4 hours after mixing. The samples were clear and colorless when viewed in normal fluorescent room light and when viewed with a Tyndall beam. Measured turbidity remained unchanged; particulate cont

Related Keywords: Yanping Zhang, BS, stability, Lawrence A. Trissel, BS, RPh, FASHP, palonosetron hydrochloride, gemcitabine hydrochloride, chemotherapy agents, fluorouracil

Related Categories: CANCER AND AIDS, GASTROENTEROLOGY, PEER-REVIEWED, STABILITIES, COMPATIBILITIES

Purchase this article for download in electronic PDF format from IJPC at for $25 at:
http://www.ijpc.com/Products/ProductAddToCart.cfm?PID=2232

Search the entire IJPC archive by keyword, topic, or issue at:
http://ijpc.com/Products