Download in electronic PDF format for $35



Search the Complete Journal Archives

Compounding and Comparative Study of a Superior, Faster, and More Adaptable Lidocaine Dental Gel Formulation

Author(s):  Rashid Mamoon, Hossain Mohammad Faisal, Nounou Mohamed, Rahman Mehbuba, Sarkar Sushanta, Adeyemo Akinola, Mullins Randy

Issue:  May/Jun 2019 - Volume 23, Number 3
View All Articles in Issue

Abstract:  Compounding perfection confirms a safe, swift, and efficacious delivery of personalized compounded medication. A large variability of the potency of the finished product may stem from complicated formulation or difficult-to-adopt methods. Also, the formulation and compounding method may adversely affect the amount of time needed to finish the compounding and dispense the medication for the patient. This study involves the development of a novel formulation and compounding method of lidocaine hydrochloride 2% dental gel and compares it with an older, more common formulation which contains five times more alcohol and four times more gelling material. Student-pharmacists were recruited in this study, and the finished products were compared in terms of their intra-group potency uniformity, time needed to finish the compounding, and post-compounding psychometric feedback by the compounders. Each compounder participated in both of the formulation methods in a crossover fashion. Our result indicates that the new formulation and the associated method enables the compounders to produce products with less variation, requiring statistically significantly less compounding time and better acceptability by the compounder.

Related Keywords: Mamoon Rashid, PhD, Mohammad Faisal Hossain, PhD, Mohamed Nounou, PhD, Mehbuba Rahman, PharmD, Sushanta Sarkar, PharmD Candidate, Akinola Adeyamo, PharmD Candidate, Randy Mullins, PharmD, FASCP, lidocaine hydrochloride 2% dental gel, oral pain, mouth sores, pain relief, mucosal ulcers, formulations, tooth pain, alcohol, compounding time, pharmacy students

Related Categories: DENTAL, EAR NOSE THROAT, FORMULATIONS, PAIN MANAGEMENT, PEER-REVIEWED, DOSAGE FORMS/DRUG CARRIERS

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Compounding and Comparative Study of a Superior, Faster, and More Adaptable Lidocaine Dental Gel Formulation Rashid Mamoon, Hossain Mohammad Faisal, Nounou Mohamed, Rahman Mehbuba, Sarkar Sushanta, Adeyemo Akinola, Mullins Randy May/Jun 2019 250-257 Buy
Development and Validation of a Stability-indicating High-performance Liquid Chromatographic Method for Quantification of Progesterone in Compounded Glycerinated Gelatin Troches Burrows Anna C, Yellepeddi Venkata Kashyap, Snyder Spencer, Wakefield Meagan, Jackson David, Huynh Johnny, Nguyen Khoa, Sayre Casey L Jul/Aug 2019 340-350 Buy
High-Performance Liquid Chromatographic Method Optimization for Ondansetron Assay in Extemporaneous Topical Gel and in Marketed Products Quamrun Masuda, Mamoon Rashid, Nasheed Shams, Mullins Randy Nov/Dec 2014 520-525 Buy
Pain: Systematic Review of Pharmacy Compounding of Pain Medication Shawaqfeh Mohammad S, Harrington Catherine Jan/Feb 2018 19-24 Buy
Efficacy and Clinical Value of Commonly Used Ingredients in Pain Management Compounds: A Literature Review Beshay Sarah M, Rivera Gerard, Balthasar Jan, Florea Naomi Jul/Aug 2015 295-300 Buy
Safe Cytotoxic Drug Preparation Using a Closed-system Transfer Device: Technical and Practical Evaluation of a New Device (Vialshield/Texium) Comparatively to a Reference One (Phaseal) Garrigue Philippe, Montana Marc, Ventre Christophe, Savry Amadine, Gauthier-Villano Laurence, Pisano Pascale, Pourroy Bertrand Mar/Apr 2016 148-154 Buy
Compatibility of Baclofen, Carvedilol, Hydrochlorothiazide, Mercaptopurine, Methadone Hydrochloride, Oseltamivir Phosphate, Phenobarbital, Propranolol Hydrochloride, Pyrazinamide, Sotalol Hydrochloride, Spironolactone, Tacrolimus Monohydrate, Ursodeoxycholic Acid, and Vancomycin Hydrochloride Oral Suspensions Compounded with SyrSpend SF pH4 Polonini Hudson, da Silva Sharlene Loures, Brandão Marcos Antônio Fernandes, Bauters Tiene, De Moerloose Barbara, Ferreira Anderson de Oliveira Nov/Dec 2018 516-526 Buy
Comparison of Rheological and Sedimentation Behavior of Commercially Available Suspending Vehicles for Oral Pharmaceutical Preparations Visser J Carolina, ten Seldam Inge E J, van der Linden Isabella J, Hinrichs Wouter L J, Veenendaal Reinier F H, Dijkers Eli C F, Woerdenbag Herman J May/Jun 2018 247-251 Buy
Compounding for Diabetic Patients:An Interview with Paul Lofholm, PharmD Allen Loyd V Jr Nov/Dec 1997 381-385 Buy
Stability of Extemporaneously Prepared Hydroxycarbamide Oral Suspensions Kabiche Djamila, Balde Issa-Bella, Majoul Elyes, Kabiche Sofiane, Bourguignon Elodie, Fontan Jean-Eudes, Cisternino Salvatore, Schlatter Joel Mar/Apr 2017 160-163 Buy