Download in electronic PDF format for $35



Search the Complete Journal Archives

Basics of Sterile Compounding: Vehicles Used in Sterile Compounding

Author(s):  Allen Loyd V Jr

Issue:  May/Jun 2019 - Volume 23, Number 3
View All Articles in Issue

Abstract:  The primary component of most compounded preparations is the vehicle. Vehicles are critical in delivering the active pharmaceutical ingredient to the patient. For liquid preparations, water is the most common vehicle followed by co-solvent systems containing water-miscible ingredients and then the non-miscible oils are used. There are different purposes and advantages for each vehicle in developing a formulation involving solutions of a drug. In developing a formulation, there are some characteristics that must be considered including pH, endotoxin load, sterility issues, and even the labeling of the vehicle being used. The vehicle has a direct impact on the delivery and stability of the finished preparation so they must be carefully evaluated for appropriateness in each specific formulation.

Related Keywords: Loyd V. Allen, Jr., PhD, RPh, compounded sterile preparations, dosage forms, sterilization, preservatives, microbial contamination, pharmaceutical waters, United States Pharmacopeia, aqueous preparations, nonaqueous–water miscible preparations, nonaqueous–water immiscible preparations, vehicles for injection, Ringer's injection, Lactated Ringer's injection, Hartmann solution, formulations, solubility

Related Categories: EXCIPIENTS, STERILE PREPARATIONS, QUALITY CONTROL, UNITED STATES PHARMACOPEIA CONVENTIONS

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Quality Control Analytical Methods: Aqua Pura: Water Purification Systems and United States Pharmacopeia Waters for the Compounding Pharmacy, Part 2: USP Waters: Experts at the United States Pharmacopeia Answer Compounders' Questions Schnatz Rick, Hernandex-Cardoso Antonio May/Jun 2011 224-232 Buy
Basics of Sterile Compounding: Vehicles Used in Sterile Compounding Allen Loyd V Jr May/Jun 2019 221-228 Buy
Quality Control Analytical Methods: Aqua Pura: Water Purification Systems and United States Pharmacopeia Waters for the Compounding Pharmacy, Part 1 Latta Kenneth S, Cabaleiro Joe, Whitehead Paul, Edison Doug Mar/Apr 2011 133-144 Buy
Basics of Compounding: Considerations for Implementing United States Pharmacopeia Chapter <797> Pharmaceutical Compounding--Sterile Preparations, Part 5: Verification of Accuracy, Sterility, and Sterilization of Compounded Preparations Allen Loyd V Jr, Okeke Claudia C Jan/Feb 2008 54-60 Buy
Considerations for Implementing United States Pharmacopeia Chapter <797> Pharmaceutical Compounding--Sterile Preparations, Part 3: Risk Levels Allen Loyd V Jr, Okeke Claudia C Sep/Oct 2007 404-410 Buy
Quality-Control Analytical Methods: Aqua Pura: Water Purification Systems and United States Pharmacopeia Waters for the Compounding Pharmacy, Part 3: Testimonials and Comparisons James Kate, Allred Richard, Latta Kenneth S, McElhiney Linda F, Olson Jacob, Hall Richard M, Baker Chad, Armstrong Nicholas, Janik Peter, Whitehead Paul, Purcell Julian Sep/Oct 2011 390-407 Buy
Basics of Compounding: Considerations for Implementing United States Pharmacopeia Chapter <797> Pharmaceutical Compounding--Sterile Preparations, Part 7: Microbial Contamination Risk Levels, 12-Hour Use, and Immediate Use Allen Loyd V Jr, Okeke Claudia C May/Jun 2008 252-257 Buy
Basics of Compounding: Implementing United States Pharmacopeia Chapter <1163> Quality Assurance in Pharmaceutical Compounding, Part 1 Allen Loyd V Jr Mar/Apr 2012 146-150 Buy
Quality Control Analytical Methods: End-preparation Assessments and Tests for Compounded Sterile Preparations McElhiney Linda F Jul/Aug 2013 307-311 Buy
Update on the Proposed Revision Process for United States Pharmacopeia Chapter <797> Pharmaceutical Compounding--Sterile Preparations Okeke Claudia C Jul/Aug 2007 302-305 Buy