Download in electronic PDF format for $25

Kalchem International - Chemicals and Compounding Supplies

Search the Complete Journal Archives

Compounded Orodispersible Films with Natural Ingredients for Halitosis: A Clinical Experience

Author(s):  Apolinário Régis De Souza, Chaves Maria Das Graças Afonso Miranda, Gonçalves Hanny Reis Mockdeci, Martins Isadora Conde Ferreria, De Paula Renée Mazilão, Granato Ana Paula Alves, Polonini Hudson Caetano, Brandão Marcos Antônio Fernandes, Ferreira Anderson De Oliveira, Raposo Nádia Rezende Barbosa

Issue:  Nov/Dec 2018 - Volume 22, Number 6
View All Articles in Issue

Abstract:  Halitosis can be described as unpleasant odors emanating from the oral cavity. It is usually associated with decomposition action of bacteria present mainly on the back of the tongue and periodontal pockets, and able to produce volatile sulfur compounds. We conducted a study at the Faculty of Dentistry, Federal University of Juiz de Fora and evaluated the therapeutic effect of two natural extracts, Camellia sinensis (green tea) and resveratrol in the form of oral polymer films, to control halitosis. Fifty volunteers (students of health courses) participated in the research after orientation and signing the informed consent form. The anamnesis was made by researchers. The physical examination was made to verify the inclusion criteria. Each participant received 45 polymeric films to be consumed in 15 days (3 films per day). Measurements of the volatile sulfur compound levels were performed using a halimeter in two stages: 1) before use and 2) 15 days after the first administration. Results showed a statistically significant reduction in volatile sulfur compound levels in 71.79% of the volunteers. We concluded that the compounded orodispersible films containing green tea and resveratrol demonstrated excellent results in reducing halitosis.

Related Keywords: Régis De Souza Apolinário, DMD, Maria Das Graças Afonso Miranda Chaves, DMD, PhD, Hanny Reis Mockdeci Gonçalves, DMD, MSc PhD (Candidate), Isadora Conde Ferreira Martins, DMD, Renée Mazilão De Paula, DMD, Ana Paula Alves Granato, DMD, Hudson Caetano Polonini, BPharm, PhD, Marcos Antônio Fernandes Brandão, BPharm, PhD, Anderson De Oliveira Ferreira, BPharm, PhD, Nádia Rezende Barbosa Raposo, BPharm, PhD, halitosis, bad breath, oral cavity, Camellia sinensis, green tea, polyphenols, resveratrol, oral polymer films, buccal strips, volatile sulfur compounds, orodispersible films, antimicrobial action, microbial load, bacterial infection

Related Categories: DENTAL, EAR NOSE THROAT, PEER-REVIEWED, DOSAGE FORMS/DRUG CARRIERS

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Compounded Orodispersible Films with Natural Ingredients for Halitosis: A Clinical Experience Apolinário Régis De Souza, Chaves Maria Das Graças Afonso Miranda, Gonçalves Hanny Reis Mockdeci, Martins Isadora Conde Ferreria, De Paula Renée Mazilão, Granato Ana Paula Alves, Polonini Hudson Caetano, Brandão Marcos Antônio Fernandes, Ferreira Anderson De Oliveira, Raposo Nádia Rezende Barbosa Nov/Dec 2018 512-515 Buy
Stability of Alprazolam, Atropine Sulfate, Glutamine, Levofloxacin, Metoprolol Tartrate, Nitrofurantoin, Ondansetron Hydrochloride, Oxandrolone, Pregabaline, and Riboflavin in SyrSpend SF pH4 Oral Suspensions de Oliveira Ferreira Anderson, Polonini Hudson C, Loures da Silva Sharlene, Cerqueira de Melo Victor Augusto, de Andrade Laura, Fernandes Brandão Marcos Antônio May/Jun 2017 255-263 Buy
Pharmaceutical Compounding in Portuguese Community Pharmacies: Characterization and Future Perspectives Palmeira-de-Oliveira Rita, Macedo Marina, Machado Rita M, Pacheco Ana Filipa, Palmeira-de-Oliveira Ana, Martinez-de-Oliveira José, Duarte Paulo Mar/Apr 2016 114-122 Buy
Compatibility of Baclofen, Carvedilol, Hydrochlorothiazide, Mercaptopurine, Methadone Hydrochloride, Oseltamivir Phosphate, Phenobarbital, Propranolol Hydrochloride, Pyrazinamide, Sotalol Hydrochloride, Spironolactone, Tacrolimus Monohydrate, Ursodeoxycholic Acid, and Vancomycin Hydrochloride Oral Suspensions Compounded with SyrSpend SF pH4 Polonini Hudson, da Silva Sharlene Loures, Brandão Marcos Antônio Fernandes, Bauters Tiene, De Moerloose Barbara, Ferreira Anderson de Oliveira Nov/Dec 2018 516-526 Buy
Stability of Allopurinol, Amitriptyline Hydrochloride, Carbamazepine, Domperidone, Isoniazid, Ketoconazole, Lisinopril, Naproxen, Paracetamol (Acetaminophen), and Sertraline Hydrochloride in SyrSpend SF PH4 Oral Suspensions Polonini Hudson C, Loures Sharlene, de Araujo Edson Peter, Brandão Marcos Antônio F, Ferreira Anderson O Sep/Oct 2016 426-434 Buy
Utilization of Compounded Medications in an Oral Medicine Practice Stock Shannon, Rubino Katie, Woo Sook-Bon, Margolis Arthur, Thomas Irena, Aboalela Ali, Treister Nathaniel Mar/Apr 2016 155-158 Buy
PostScription: Setting up a National System of Compounding Pharmacies: An Introduction Guedes de Souza Hugo, Favaro Alvaro Jr, Andrade Alba Livia, Gomes Lenir Yago, de Souza Aguiar Simone, do Carmo Garcez Maria Sep/Oct 2009 447 Buy
Setting Up a National System of Compounding Pharmacies: Preventing Error, Assuring Quality, Building Trust Guedes de Souza Hugo, Favaro Alvaro Jr, Andrade Alba Livia, Gomes Lenir Yago, de Souza Aguiar Simone, do Carmo Garcez Maria Nov/Dec 2009 532-536 Buy
Stability of Acetazolamide, Baclofen, Dipyridamole, Mebeverine Hydrochloride, Propylthiouracil, Quinidine Sulfate, and Topiramate Oral Suspensions in SyrSpend SF PH4 de Oliveira Ferreira Anderson, Polonini Hudson, Loures da Silva Sharlene, Buzinari Aglio Natália Cristina, Abreu Jordana, Fernandes Brandão Marcos Antônio Jul/Aug 2017 339-346 Buy
PostScription: The Compounding Pharmacy in Brazil: A Pharmacist's Perspective Guedes de Souza Hugo, do Carmo Garcez Maria, Pinheiro Vanessa A Jan/Feb 2009 87-88 Buy