Download in electronic PDF format for $35



Search the Complete Journal Archives

A Cold Process Preparation of Vetiveria zizanioides (L.) Nash Oil Lotions using Simulgel FL as an Emulsifier

Author(s):  Songkro Sarunyoo, Pengmak Somuredee, Seajung Pornyamol, Maneenuan Duangkhae, Kaewnopparat Nattha

Issue:  Sep/Oct 2018 - Volume 22, Number 5
View All Articles in Issue

Abstract:  Vetiveria zizanioides (vetiver) contains viscous volatile oil, which has the ability to repel mosquitoes similar to citronella oil, a well-known mosquito repellent in tropical countries, like Thailand. The objectives of the current study were to formulate the stable oil-in-water vetiver oil lotions using Simulgel FL as a liquid emulsifier, to investigate the physicochemical properties of the prepared lotions and to evaluate the in vitro release characteristics of the stable vetiver oil lotions. In this work, the concentrations of Simulgel FL ranged from 1% to 3% weight in weight, whereas the concentrations of vetiver oil were varied: 2.5%, 5%, and 10% weight in weight. The suitable concentration of Simulgel FL was found to be 3% weight in weight. For comparison purposes, oil-in-water citronella oil lotions (10% weightin- weight citronella oil) were also prepared with similar ingredients. A mixture of vetiver oil and citronella oil (1:1 by weight) was also used as an active ingredient. By using Simulgel FL, the lotions could be prepared using a cold process (without heat). The physicochemical properties (appearance, pH, viscosity) of the stable lotions were satisfactory. All prepared lotions possessed weak acidic pH values with pseudoplastic flows. Using modified Franz diffusion cell and synthetic membrane, the release rates of vetiver oil were relatively lower than those of citronella oil.

Related Keywords: Sarunyoo Songkro, PhD (Pharmacy), Somuredee Pengmak, Bachelor of Science (Pharmacy), Pornyamol Seajung, Bachelor of Science (Chemistry), Duangkhae Maneenuan, Bachelor of Science (Chemistry), Nattha Kaewnopparat, Master of Science (Pharmacy), Vetiveria zizanioides, vetiver, mosquito repellant, liquid emulsifier, emulsification, lotion, topical preparation, khus khus, vetivert, tropical grass, medicinal plant, botanical pesticide, traditional medicine, citronella, xanthan gum, physical stability, Fang Zhao, PhD, Vivek S. Dave, PhD, Mazin Z. Mar, PharmD Candidate, Jonathan R. Perri, BS Candidate, eslicarbazepine acetate, anticonvulsant agent, seizure disorders, partial-onset seizures, children, adolescents, oral suspension, suspension vehicles, storage conditions, physical stability, chemical stability, formulation

Related Categories: EXCIPIENTS, PEER-REVIEWED, STABILITIES, COMPATIBILITIES

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
A Cold Process Preparation of Vetiveria zizanioides (L.) Nash Oil Lotions using Simulgel FL as an Emulsifier Songkro Sarunyoo, Pengmak Somuredee, Seajung Pornyamol, Maneenuan Duangkhae, Kaewnopparat Nattha Sep/Oct 2018 424-432 Buy
PreScription: Putting the Science Back into Pharmacy Allen Loyd V Jr Mar/Apr 2007 92 Buy
Remington: The Science and Practice of Pharmacy: From the Past into the Future Allen Loyd V Jr Sep/Oct 2012 358-362 Buy
PostScription: The Importance of Science in the Pharmacy Curriculum Stockton Shelly J Mar/Apr 2012 174-175 Buy
PreScription: The Science and Technology of Hospital Pharmacy Newsletter Allen Loyd V Jr Jul/Aug 2011 268 Buy
Agar Transfer Devices for Environmental Sampling in the Compounding Pharmacy: Science and Compliance Grilli Anthony, Sutton Scott Jan/Feb 2015 30-37 Buy
Putting the Science Back into the "Art and Science" of Compounding Kastango Eric S Jul/Aug 2006 263-268 Buy
Owning an In-Network Pharmacy and a Second Out-of-Network Pharmacy that Performs Compounding: Suggestions on How to Avoid Being Terminated from the Pharmacy Benefits Manager Network Levitt Jonathan E, Mizeski Todd Mar/Apr 2010 134 Buy
PreScription: Potpourri of Opinions…From Many Allen Loyd V Jul/Aug 2015 266 Buy
PostScription: Guidance to Achieve Accreditation from the Pharmacy Compounding Accreditation Board Pharmacy Compounding Accreditation Board Sep/Oct 2010 440-441 Buy