Download in electronic PDF format for $25

Kalchem International - Chemicals and Compounding Supplies

Search the Complete Journal Archives

Stability of Extemporaneously Prepared Sodium Benzoate Oral Suspension

Author(s):  Atkins Julia R, Lull Melinda E, Decker Andrew S, Hutchinson David J

Issue:  Jul/Aug 2018 - Volume 22, Number 4
View All Articles in Issue

Abstract:  The stability of extemporaneously prepared sodium benzoate oral suspension in cherry syrup and Ora-Sweet was studied. Oral solutions of 250-mg/mL sodium benzoate were prepared in either cherry syrup or Ora-Sweet. To a beaker, 50 grams of Sodium Benzoate Powder USP was dissolved and filtered, the solution was divided equally into two parts, and each aliquot was added into two separate calibrated 100-mL amber vials. In the first vial, cherry syrup was added to make a final volume of 100 mL. In the second vial, Ora-Sweet was added to give a final volume of 100 mL. This process was repeated to prepare three solutions of each kind and all were stored at room temperature. A 250-┬ÁL sample was withdrawn immediately after preparation and again at 7, 14, 28, 60, and 90 days for each sample. At each time point, further dilution was made to an expected concentration of 0.25 mg/mL with sample diluent, and the samples were assayed in triplicate by stability-indicating high-performance liquid chromatography. Stability was defined as the retention of at least 90% of the initial concentration. At least 92% of the initial concentration of sodium benzoate in cherry syrup and at least 96% of the sodium benzoate in Ora-Sweet remained throughout the 90-day study period. There were no detectable changes in color and no visible microbial growth in any sample. Extemporaneously compounded suspensions of sodium benzoate in cherry syrup or Ora-Sweet were stable for at least 90 days when stored in a 4-oz amber plastic bottle at room temperature in reduced lighting.

Related Keywords: Julia R. Atkins, BS, PharmD Candidate, Melinda E. Lull, PhD, Andrew S. Decker, PharmD, David Hutchinson, PharmD, BCPS, BCPPS, sodium benzoate, urea cycle disorders, nitrogenous waste, nitrogen ammonia scavenger, formulation, stability

Related Categories: FORMULATIONS, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, STORAGE, UROLOGY/URINARY TRACT

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Stability of Extemporaneously Prepared Sodium Benzoate Oral Suspension Atkins Julia R, Lull Melinda E, Decker Andrew S, Hutchinson David J Jul/Aug 2018 326-328 Buy
Compounding for Diabetic Patients:An Interview with Paul Lofholm, PharmD Allen Loyd V Jr Nov/Dec 1997 381-385 Buy
Comparative Stability of Vitamin K1 Oral Liquids Prepared in Sterile Water for Injection and Stored in Amber Glass Bottles and Amber Plastic Syringes Huffman Jessica, Brown Stacy, Lewis Paul, Lawson Sarah, Ogle Amanda, Peacock Gina Jul/Aug 2018 340-344 Buy
Stability of Ribavirin for Inhalation Packaged in Syringes or Glass Vials when Stored Frozen, Refrigerated, and at Room Temperature Larson Bayli, Bushman Lane R, Casciano Matthew L, Oldland Alan R, Kiser Jennifer J, Kiser Tyree H Nov/Dec 2016 521-525 Buy
Stability of Extemporaneously Prepared Hydroxycarbamide Oral Suspensions Kabiche Djamila, Balde Issa-Bella, Majoul Elyes, Kabiche Sofiane, Bourguignon Elodie, Fontan Jean-Eudes, Cisternino Salvatore, Schlatter Joel Mar/Apr 2017 160-163 Buy
Safe Cytotoxic Drug Preparation Using a Closed-system Transfer Device: Technical and Practical Evaluation of a New Device (Vialshield/Texium) Comparatively to a Reference One (Phaseal) Garrigue Philippe, Montana Marc, Ventre Christophe, Savry Amadine, Gauthier-Villano Laurence, Pisano Pascale, Pourroy Bertrand Mar/Apr 2016 148-154 Buy
Novel Approaches to Topical Psoriasis Therapy Koyama Gregory, Liu Jenny, Scaffidi Alyse, Khazraee Maryam, Epstein Benjamin Sep/Oct 2015 357-365 Buy
Kinetic Analysis of Drug Release from Compounded Slow-release Capsules of Liothyronine Sodium (T3) Bakhteyar Hamid, Cassone Clayton, Kohan Hamed Gilzad, Sani Shabnam N Sep/Oct 2017 418-425 Buy
Stability of Dexmedetomidine in 0.9% Sodium Chloride in Two Types of Intravenous Infusion Bags Marquis Kathleen, Hohlfelder Benjamin, Szumita Paul M Sep/Oct 2017 436-439 Buy
Stability Assessment of Repackaged Bevacizumab for Intravitreal Administration Pereboom Marieke, Becker Matthijs L, Amenchar Mostapha, Verweij Sjoerd L, van der Hoeven Ruud TM, Mulder Inge J Jan/Feb 2015 70-72 Buy