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Development and Application of a High-Performance Liquid Chromatography Stability-Indicating Assay for Beyond-Use Date Determination of Compounded Topical Gels Containing Multiple Active Drugs

Author(s):  Gorman Gregory,Sokom Simara,Coward Lori,Arnold John J

Issue:  Mar/Apr 2017 - Volume 21, Number 2
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Abstract:  Topical gels compounded by pharmacists are important clinical tools for the management of pain. Nevertheless, there is often a dearth of information about the chemical stability of drugs included in these topical formulations, complicating the assignment of beyond-use dating. The purpose of this study was to develop a high-performance liquid chromatography photodiode array–based stability-indicating assay that could simultaneously resolve six drugs (amitriptyline, baclofen, clonidine, gabapentin, ketoprofen, lidocaine) commonly included in topical gels for pain management and their potential degradation products. Furthermore, this method was applied to the determination of beyond-use dating of combinations of these drugs prepared in commonly utilized bases (Lipobase, Lipoderm, Pluronic organogel). Gabapentin was determined to be the least stable component in all formulations tested. Measured stability ranged between 7 to 49 days depending on the base and other active drugs present in the formulation. In the absence of gabapentin, baclofen was the next least stable component, lasting for 120 days, regardless of the type of formulating base used.

Related Keywords: Gregory Gorman, PhD, Simara Sokom, PharmD, Lori Coward, BS, John J. Arnold, PhD, stability-indicating assay, HPLC, topical preparations, topical vehicle, topical gels, pain management, transdermal penetration, stability, baclofen, ketoprofen, gabapentin, amitriptyline, clonidine, lidocaine hydrochloride, drug admixtures, multidrug formulations, beyond use date

Related Categories: PAIN MANAGEMENT, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, DOSAGE FORMS/DRUG CARRIERS, NEUROLOGY

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