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Basics of Sterile Compounding: Biopharmaceutics of Injectable Dosage Forms

Author(s):  Akers Michael J

Issue:  Jan/Feb 2017 - Volume 21, Number 1
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Abstract:  Biopharmaceutics studies the relationship between the drug product and what happens after the product is administered. Since the majority of injectables are administered by the intravenous route, thus avoiding the need for drug absorption, not many articles are published compared to other routes of drug administration. However, other routes of administration for drug injection are becoming more frequent because of greater commercial availability of sustained- and controlled-release drug delivery systems. This article reviews basic principles of drug absorption, distribution, metabolism, and elimination of injectable drugs and certain physicochemical and physiological factors affecting injectable drug biopharmaceutics.

Related Keywords: Michael J. Akers, PhD, biopharmaceutics, injectables, drug absorption, drug distribution, pharmacokinetics, routes of administration, sustained release, controlled release, passive diffusion, blood circulation, circulatory system, receptor binding, plasma proteins, tight junctions, blood-brain barrier, drug availability, drug metabolism, drug excretion, drug solubility, partition coefficient, particle size, viscosity, solid state morphology, osmolality, injection volume, dosage form, molecular size, aqueous solutions, aqueous suspensions, oily solutions, oily suspensions, oil-in-water emulsions, water-in-oil emulsions, complexes, polymeric systems, liposomes, microparticulate delivery systems, drug delivery systems, biological half-life, vascular perfusion


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