Download in electronic PDF format for $25



Search the Complete Journal Archives

A Novel Vehicle for Enhanced Drug Delivery Across the Human Nail for the Treatment of Onychomycosis

Author(s):  Turner Rob,Weaver Sean,Caserta Francesco,Brown Marc B

Issue:  Jan/Feb 2016 - Volume 20, Number 1
View All Articles in Issue

Abstract:  The aim of this study was to use in vitro nail models to investigate the potential of a novel base formulation (Recura) containing either fluconazole or miconazole for the treatment of onychomycosis in comparison to two commercial comparators (Jublia and a Penlac generic). Initially, a modified Franz cell was used, where sections of human nail served as the barrier through which drug penetrated into an agar-filled chamber infected with dermatophytes. A second study was performed using a novel infected nail model where dermatophytes grew into human nail and adenosine triphosphate levels were used as biological marker for antimicrobial activity. The novel enhancing system Recura increased the permeation of both existing drugs through human nail sections mounted in a modified Franz cell. Furthermore, the infected nail model also confirmed that the system also enhanced the permeation through infected nail resulting in a decrease in adenosine triphosphate levels superior (P =0.05) to Penlac generic and equivalent (P >0.05) to the commercial comparator Jublia. This study demonstrated that with the use of a novel permeation-enhancing formulation base, Recura enhances delivery of miconazole and fluconazole when applied ungually such that the efficacy was equivalent or superior to commercial comparators. Such a topically applied system has the possibility of overcoming the systemic side effects of antifungals when taken orally.

Related Keywords: Rob Turner, PhD, Sean Weaver, PhD, Francesco Caserta, PhD, Marc B. Brown, PhD, CChem, FRSC, drug delivery, nail penetration, onychomycosis, nail fungus, nail models, nail permeation, antifungal, miconazole, fluconazole, ungual application, fungal infection, Turchub assay

Related Categories: DERMATOLOGY, EXCIPIENTS, PEER-REVIEWED, DOSAGE FORMS/DRUG CARRIERS, INFECTIOUS DISEASE

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
A Novel Vehicle for Enhanced Drug Delivery Across the Human Nail for the Treatment of Onychomycosis Turner Rob, Weaver Sean, Caserta Francesco, Brown Marc B Jan/Feb 2016 71-80 Buy
Ciclopirox 10% in Isopropyl Alcohol Nail Solution Allen Loyd V Jr Mar/Apr 2010 152 Buy
Terbenafine Hydrochloride Bilayer Nail Lacquer Allen Loyd V Jr Jan/Feb 2011 72 Buy
Physico-chemical Stability of MabThera Drug-product Solution for Subcutaneous Injection under In-use Conditions with Different Administration Materials Mueller Claudia, Dietel Elde, Heynen Severin R, Nalenz Heiko, Goldbach Pierre, Mahler Hanns-Christian, Schmidt Johannes, Grauschopf Ulla, Schoenhammer Karin May/Jun 2015 261-267 Buy
Stability of Two Antifungal Agents, Fluconazole and Miconazole, Compounded in HUMCO RECURA Topical Cream to Determine Beyond-Use Date Gautam Pradeep, Light Bob, Purvis Troy Mar/Apr 2017 154-159 Buy
Rapid-Dissolve Technology: An Interview With Loyd V. Allen, Jr., PhD, RPh Allen Loyd V Jr Nov/Dec 2003 449-450 Buy
Nail Fungus Solution Nelson James L Jul/Aug 1998 277 Buy
Skin Permeation and Antinociception of Compounded Topical Cyclobenzaprine Hydrochloride Formulations Bryson Evan, Hartman Rachel, Arnold John, Gorman Greg, Sweitzer Sarah.Asbill Scott Mar/Apr 2015 161-166 Buy
Use of a Closed-system Drug Transfer Device (PhaSeal) and Impact on Preparation Time Sanchez-Rubio Ferrandez J, Lozano M C, Iglesias I, Sanchez-Rubio Ferrandez L, Rodriguez Vargas B, Moreno Diaz R Sep/Oct 2012 431-433 Buy
Safe Cytotoxic Drug Preparation Using a Closed-system Transfer Device: Technical and Practical Evaluation of a New Device (Vialshield/Texium) Comparatively to a Reference One (Phaseal) Garrigue Philippe, Montana Marc, Ventre Christophe, Savry Amadine, Gauthier-Villano Laurence, Pisano Pascale, Pourroy Bertrand Mar/Apr 2016 148-154 Buy