Download in electronic PDF format for $25



Search the Complete Journal Archives

Basic Principles of Lyophilization, Part 1

Author(s):  Akers Michael J

Issue:  Nov/Dec 2015 - Volume 19, Number 6
View All Articles in Issue

Abstract:  The achievement of a high-quality lyophilized (freezedried) dosage form involves the combination of optimal formulation design and optimal freeze-dry cycle design. This 2-part article describes how this can be done. Part 1 discusses the basic principles and procedures of lyophilization up to a discussion on the different stages of lyophilization. The stages of lyophilization are discussed in part 2.

Related Keywords: Michael J. Akers, PhD, lyophilization, freezing-drying, freeze dried, freeze-dry cycle, parenteral drugs, biopharmaceuticals, stability, vacuum, volatile compounds, compounded sterile preparations, small molecules, large molecules, buffering agents, surface-active agents, competitive-binding agents, proteins, cyroprotectants, amino acids, polymers, polyols, sugars, polyethylene glycol, lyoprotectants

Related Categories: EXCIPIENTS, STABILITIES, COMPATIBILITIES, STORAGE

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Basic Principles of Lyophilization, Part 1 Akers Michael J Nov/Dec 2015 471-476 Buy
Basics of Compounding for Dry-Skin Conditions Allen Loyd V Jr Nov/Dec 2003 460-463 View Sample
Basic Principles of Lyophilization, Part 2 Akers Michael J Jan/Feb 2016 20-27 Buy
Basics of Sterile Compounding: Manipulating Peptides and Proteins Akers Michael J May/Jun 2017 223-228 Buy
Basics of Sterile Compounding: Excipients Used in Injections Akers Michael J Jul/Aug 2017 301-308 Buy
Formulation and Stability of Solutions Akers Michael J Jan/Feb 2016 41-45 Buy
Basics of Compounding: Basics of Compounding with Complex Organic Molecules Allen Loyd V Jr May/Jun 2011 234-238 Buy
Compounding in the Pharmacy Curriculum: Beyond the Basics Hinkle Amanda R, Newton Gail D May/Jun 2004 181 Buy
Basics of Sterile Compounding: Particulate Matter Akers Michael J Sep/Oct 2017 395-404 Buy
Accuracy Considerations in Sterile Compounding Akers Michael J Mar/Apr 2017 133-142 Buy