Download in electronic PDF format for $25



Search the Complete Journal Archives

Sterile Filtration

Author(s):  Akers Michael J

Issue:  Sep/Oct 2015 - Volume 19, Number 5
View All Articles in Issue

Abstract:  The great majority of sterile products commercially available as well as prepared in compounding pharmacies are sterilized by sterile filtration during aseptic processing. This brief and basic review will highlight the nature, action, and use of sterilizing filters. Special emphasis is given to how filters are validated in producing a sterile filtrate while being compatible with the filtered solution, as well as how filters are integrity tested during aseptic processing.

Related Keywords: Michael J. Akers, PhD, compounded sterile preparations, sterile filtration, particle filters, microfilters, ultrafilters, nanofilters, filter porosity, filter efficiency, filter material, filter membrane thickness, filter validation, bacterial retention destructive testing, in process filter integrity testing, bubble-point test, diffusion test, forward flow test, retention test apparatus, microbe contamination, microbial reduction, surface-active agents, amphiphilic wetting agents

Related Categories: STERILE PREPARATIONS, TECHNOLOGY, QUALITY CONTROL

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Sterile Filtration Akers Michael J Sep/Oct 2015 393-401 Buy
Basics of Sterile Compounding: Particulate Matter Akers Michael J Sep/Oct 2017 395-404 Buy
Basics of Sterile Compounding: Aseptic Processing Akers Michael J Jan/Feb 2015 49-56 Buy
Paclitaxel Compatibility with IV Express Filter Unit Xu Quanyun A, Trissel Lawrence A, Zhang Yanping May/Jun 1998 243-245 Buy
Sorption of Benzalkonium Chloride to Various Filters Used in Ophthalmics Prince Shelly J, Allen Loyd V Jr May/Jun 1998 249-251 Buy
Basics of Sterile Compounding: Bubble Point Testing Thoma Laura Jan/Feb 2014 54-57 Buy
Accuracy Considerations in Sterile Compounding Akers Michael J Mar/Apr 2017 133-142 Buy
Pharmacy Compounding Urban Legends Kastango Eric S Jan/Feb 2006 32-34 Buy
Basics of Sterile Compounding: Manipulating Peptides and Proteins Akers Michael J May/Jun 2017 223-228 Buy
Basics of Sterile Compounding: Personnel Requirements for Sterile Compounding Akers Michael J Jul/Aug 2016 307-314 Buy