Download in electronic PDF format for $25



Search the Complete Journal Archives

Assessing the Use of Food Coloring as an Appropriate Visual Guide for Homogenously Mixed Capsule Powders in Extemporaneous Compounding

Author(s):  Hoffmann Brittany,Carlson Christie,Rao Deepa A

Issue:  Jul/Aug 2014 - Volume 18, Number 4
View All Articles in Issue

Abstract:  The purpose of this work was to assess the use of food colors as a visual aid to determine homogeneous mixing in the extemporaneous preparation of capsules. Six different batches of progesterone slow-release 200-mg capsules were prepared by different mixing methods until visually determined as homogeneous based on yellow food coloring distribution in the preparation by the Central Iowa Compounding Pharmacy, Des Moines, Iowa. UV-Vis spectrophotometry was used to extract and evaluate yellow food coloring content in each of these batches and compared to an in-house, small-batch geometric dilution preparation of progesterone slow-release 200-mg capsules. Of the 6 batches tested, only one, which followed the principles of additive dilution and an appropriate mixing time, was both visually and quantitatively homogeneous in the detection of yellow food coloring. The use of food coloring alone is not a valid quality-assurance tool in determining homogeneous mixing. Principles of geometric and/or additive dilution and appropriate mixing times along with the food color can serve as a quality-assurance tool.

Related Keywords: Brittany Hoffmann, PharmD, MBA, Christie Carlson, RPh, Deepa A. Rao, PhD, food colors, visual aid, homogenous mixing, progesterone slow-release capsules, yellow food coloring, dye, homogenous dispersion, quality assurance

Related Categories: EXCIPIENTS, PEER-REVIEWED, QUALITY CONTROL, DOSAGE FORMS/DRUG CARRIERS

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Assessing the Use of Food Coloring as an Appropriate Visual Guide for Homogenously Mixed Capsule Powders in Extemporaneous Compounding Hoffmann Brittany, Carlson Christie, Rao Deepa A Jul/Aug 2014 341-344 Buy
Solid State Stability of Extemporaneously Prepared Levothyroxine Aliquots and Capsules Fortner Jeff, Salton Jason, Carlson Christie, Wheeler Rich, Cote Brianna, Rao Deepa Sep/Oct 2015 414-419 Buy
Kinetic Analysis of Drug Release from Compounded Slow-release Capsules of Liothyronine Sodium (T3) Bakhteyar Hamid, Cassone Clayton, Kohan Hamed Gilzad, Sani Shabnam N Sep/Oct 2017 418-425 Buy
Custom-Compounded Micronized Hormones in a Slow-Release Capsule Matrix Timmons Evelyn D, Timmons Steven P Sep/Oct 2002 378 Buy
Compounding Slow-release Capsules: A Comprehensive Review and an Excel Spreadsheet for Faster Calculation of Excipients Zur Eyal Jan/Feb 2013 10-22 Buy
Release of Morphine Sulfate from Compounded Slow-Release Capsules: The Effect of Formulation on Release Bogner Robin H, Szwejkowski Jessica, Houston Alana Sep/Oct 2001 401-405 Buy
In Vitro Evaluation of Extemporaneously Compounded Slow-Release Capsules Containing Morphine Sulfate or Oxycodone Hydrochloride Glowiak Dana L, Green Julie L, Bowman Bill J Mar/Apr 2005 157-164 Buy
Selection of Color Additives: A Regulatory View Kumar Anuj, Dureja Harish, Madan Anil K Jul/Aug 2012 304-309 Buy
I See Colors: Using Vital Dyes in Diagnosing Ophthalmic Disease McElhiney Linda F May/Jun 2012 190-195 Buy
Compounding of Slow-release Niacinamide Capsules: Feasibility and Characterization Radojkovic Branko, Milic Jela, Calija Bojan Sep/Oct 2012 434-437 Buy